3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester

Base Information

Chemical Name:3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester
CAS No.:1466574-67-3
Molecular Formula:C₁₄H₁₉F₃O₂SSi
Molecular Weight:336.45
Hs Code.:

Synonyms:3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester

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Chemical Property of 3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester

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Technology Process of 3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester

There total 1 articles about 3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 187331-46-0
3-bromo-5-trifluoromethylbenzoic acid methyl ester

: 18143-30-1
2-trimethylsilylethanethiol

: 1466574-67-3
3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester

Guidance literature:: 3-bromo-5-trifluoromethylbenzoic acid methyl ester; 2-trimethylsilylethanethiol; In 1,4-dioxane; for 0.0833333h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 20 - 120 ℃; for 22h; Inert atmosphere; Sealed tube;

Reference yield: 72.0%

: 1466574-67-3
3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester

: 1466574-65-1
3-mercapto-5-trifluoromethylbenzoic acid methyl ester

Guidance literature:: 3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 1466574-67-3
3-trifluoromethyl-5-(2-trimethylsilanylethylsulfanyl)benzoic acid methyl ester

: 1466574-60-6
3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.5 h / 20 °C

3: Oxone / water; methanol / 95 h / 20 °C / Cooling with ice

With Oxone; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; acetonitrile;