3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid

Base Information

Chemical Name:3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid
CAS No.:1466574-58-2
Molecular Formula:C₁₆H₁₉F₃O₆S
Molecular Weight:396.384
Hs Code.:

Synonyms:3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid

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Chemical Property of 3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid

Chemical Property:

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Technology Process of 3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid

There total 6 articles about 3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.7%

: 1466574-60-6
3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid methyl ester

: 1466574-58-2
3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

: 187331-46-0
3-bromo-5-trifluoromethylbenzoic acid methyl ester

: 1466574-58-2
3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / 0.08 h / Inert atmosphere

1.2: 22 h / 20 - 120 °C / Inert atmosphere; Sealed tube

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.5 h / 20 °C

4.1: Oxone / water; methanol / 95 h / 20 °C / Cooling with ice

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4 h / 20 °C

With Oxone; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;

Reference yield:

: 1466574-62-8
3-(3-tert-butoxycarbonylpropylsulfanyl)-5-trifluoromethylbenzoic acid methyl ester

: 1466574-58-2
3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / water; methanol / 95 h / 20 °C / Cooling with ice

2: water; lithium hydroxide monohydrate / 1,4-dioxane / 4 h / 20 °C

With Oxone; lithium hydroxide monohydrate; water; In 1,4-dioxane; methanol; water;