Technology Process of (1R,6S,7R,8S)-N-(toluene-4-sulfonyl)-7-<(benzyloxy)methyl>bicyclo<4.3.0>nonan-8-amide
There total 11 articles about (1R,6S,7R,8S)-N-(toluene-4-sulfonyl)-7-<(benzyloxy)methyl>bicyclo<4.3.0>nonan-8-amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
for 18h;
Ambient temperature;
DOI:10.1021/jo951413z
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 99 percent / TsOH*H2O / benzene / 12 h / Heating
2: 99 percent / LiAlH4 / diethyl ether / 5 h / Ambient temperature
3: 1.) NaH / 1) DMF, room temperature, 1 h; 2) DMF, room temperature, 22 h
4: 99 percent / aq. HCl / tetrahydrofuran / 3 h / 60 °C
5: 70 percent / NaBH(OAc)3 / tetrahydrofuran; acetic acid / 1) 0-5 deg C, 1 h; 2) room temperature, 24 h
6: 77 percent / NH4OCHO / Pd/C / methanol / 3 h / Heating
7: 100 percent / Et3N / CH2Cl2 / 18 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; ammonium formate; sodium tris(acetoxy)borohydride; sodium hydride; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo951413z
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH / 1) DMF, room temperature, 1 h; 2) DMF, room temperature, 22 h
2: 99 percent / aq. HCl / tetrahydrofuran / 3 h / 60 °C
3: 70 percent / NaBH(OAc)3 / tetrahydrofuran; acetic acid / 1) 0-5 deg C, 1 h; 2) room temperature, 24 h
4: 77 percent / NH4OCHO / Pd/C / methanol / 3 h / Heating
5: 100 percent / Et3N / CH2Cl2 / 18 h / Ambient temperature
With
hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.1021/jo951413z
