(S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane

Base Information

Chemical Name:(S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane
CAS No.:121612-85-9
Molecular Formula:C₁₉H₂₂N₂O₂S
Molecular Weight:342.462
Hs Code.:

Synonyms:(S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane

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Chemical Property of (S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane

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Technology Process of (S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane

There total 9 articles about (S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 121612-80-4
5-((S)-1-Methoxymethyl-2-phenyl-ethylcarbamoyl)-7-methyl-thieno[2,3-b]pyridin-7-ium; iodide

: 121612-85-9
(S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane

Guidance literature:: With sodium dithionite; sodium carbonate; In methanol; water; for 0.333333h;

Reference yield:

: 117390-38-2
thieno<2,3-b>pyridine-5-carboxylic acid

: 121612-85-9
(S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 12 h / Heating

2: 30 percent / Et₃N / CH₂Cl₂ / 1) -20 deg C, 1 h, 2) room temperature 24 h

3: acetonitrile / 8 h / Heating

4: 97 percent / Na₂CO₃*10H₂O, Na₂S₂O₄ / methanol; H₂O / 0.33 h

With thionyl chloride; sodium dithionite; sodium carbonate; triethylamine; In methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 121612-85-9
(S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane

Guidance literature:: Multi-step reaction with 7 steps

1: LiAlH₄

3: 55 percent / NaH, 18-crown-6 ether / tetrahydrofuran / 48 h / Ambient temperature

4: 91 percent / hydrazine / ethanol / 3 h / Ambient temperature

5: 30 percent / Et₃N / CH₂Cl₂ / 1) -20 deg C, 1 h, 2) room temperature 24 h

6: acetonitrile / 8 h / Heating

7: 97 percent / Na₂CO₃*10H₂O, Na₂S₂O₄ / methanol; H₂O / 0.33 h

With lithium aluminium tetrahydride; sodium dithionite; 18-crown-6 ether; sodium hydride; sodium carbonate; triethylamine; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;