tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate

Base Information

• Chemical Name: tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate
• CAS No.: 1173088-51-1
• Molecular Formula: C₂₆H₃₃ClO₃S
• Molecular Weight: 461.065
• Mol file: 1173088-51-1.mol

Synonyms:tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate

Chemical Property of tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate

There total 1 articles about tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

allyl iodid (556-56-9) + tert-butyl 4-phenylbutanoate (16537-11-4) + 1-chlorovinyl p-tolyl sulfoxide (184705-48-4) → tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate (1173088-51-1)

Guidance literature:

tert-butyl 4-phenylbutanoate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃;

1-chlorovinyl p-tolyl sulfoxide; In tetrahydrofuran; hexane; at -78 ℃;

allyl iodid; In tetrahydrofuran; hexane;

DOI:10.1055/s-0028-1088019

Reference yield:

tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate (1173088-51-1) → 5-allyl-3-(2-phenylethyl)-5H-furan-2-one (1320211-15-1)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / 24 h / 20 °C

2: trifluoroacetic anhydride; sodium iodide / acetonitrile / -40 °C

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.5 h / 0 °C

4: pyridine / 12 h / Reflux

With pyridine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trifluoroacetic anhydride; sodium iodide; In chloroform; acetonitrile; 2: Pummerer type cyclization;

DOI:10.1055/s-0030-1259987

Reference yield:

tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)hept-6-enoate (1173088-51-1) → C22H24O2S

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 24 h / 20 °C

2: trifluoroacetic anhydride; sodium iodide / acetonitrile / -40 °C

With trifluoroacetic acid; trifluoroacetic anhydride; sodium iodide; In acetonitrile; 2: Pummerer type cyclization;

DOI:10.1055/s-0030-1259987

upstream raw materials:

allyl iodid

tert-butyl 4-phenylbutanoate

1-chlorovinyl p-tolyl sulfoxide

Downstream raw materials:

5-allyl-3-(2-phenylethyl)-5H-furan-2-one

C₂₂H₂₄O₃S