556-56-9Relevant academic research and scientific papers
Bis(allyl)aluminum cation, tris(allyl)aluminum, and tetrakis(allyl) aluminate: Synthesis, characterization, and reactivity
Lichtenberg, Crispin,Robert, Dominique,Spaniol, Thomas P.,Okuda, Jun
, p. 5714 - 5721 (2010)
Cationic, neutral, and anionic aluminum allyl compounds were synthesized, and their reactivity toward electrophiles was studied. The THF adduct of the previously elusive tris(allyl)aluminum, [Al(η1-C 3H5)3(THF)] (1), was isolated as an oil. Protonolysis of one allyl ligand in 1 using [NEt3H][BPh4] gave the cationic bis(allyl)aluminum, a fragment of the crystalline [Al(η1-C3H5)2(THF) 3-n]+[BPh4]-·(n+1)THF (n = 0, 1) (2). Single-crystal X-ray diffraction of [Al(η1-C 3H5)2(THF)2]+[BPh 4]- (2a) revealed a tetrahedral aluminum center, while [Al(η1-C3H5)2(THF) 3]+[BPh4]- (2b) contains a trigonal-bipyramidal aluminum center with both allyl ligands in the equatorial plane. The tetrakis(allyl)aluminate K+[Al(η1-C 3H5)4]- (3) was also synthesized from the reaction of 1 with K(C3H5). Reactions of the allyl compounds 1-3 with (i) benzophenone, (ii) allyl halides C 3H5X (X = Cl, Br, I), and (iii) halogen X2 (X = Br, I) showed considerable difference with respect to the ionic charge of the aluminum allyl.
Structure–activity relationships and docking studies of hydroxychavicol and its analogs as xanthine oxidase inhibitors
Nishiwaki, Keiji,Ohigashi, Kanae,Deguchi, Takahiro,Murata, Kazuya,Nakamura, Shinya,Matsuda, Hideaki,Nakanishi, Isao
, p. 741 - 747 (2018/07/05)
Hydroxychavicol (HC), which is obtained from the leaves of Piper betle LINN. (Piperaceae), inhibits xanthine oxidase (XO) with an IC50 value of 16.7μM, making it more potent than the clinically used allopurinol (IC50=30.7μM). Herein, a structure–activity relationship analysis of the polar part analogs of HC was conducted and an inhibitor was discovered with a potency 13 times that of HC. Kinetic studies have revealed that HC and its active analog inhibit XO in an uncompetitive manner. The binding structure prediction of these inhibitor molecules to the XO complex with xanthine suggested that both compounds (HC and its analog) could simultaneously form hydrogen bonds with xanthine and XO.
Iodine-mediated rearrangements of diallylsilanes
O'Neil, Gregory W.,Cummins, Elizabeth J.
, p. 3406 - 3409 (2017/08/11)
Diallylsilanes can be made to rearrange upon treatment with I2. Of the silanes tested, diallyldiphenylsilane showed the greatest propensity to undergo this intramolecular carbocation allylation process. After etherification of the initially for
The oxidative dehydrogenation of propane from a process for the preparation of propylene
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Paragraph 0039-0042, (2017/04/04)
The invention discloses a method for preparing propylene by performing oxidative dehydrogenation on propane, and relates to a method for preparing propylene. The method comprises the steps of: heating a catalyst to the temperature of 400 to 700 DEG C, keeping the temperature for 10 to 120 minutes, introducing mixed reaction gas to pass through a catalyst bed layer, and reacting to obtain the product of propylene. The mixed reaction gas propane, oxygen, hydrogen halide gas and inert gas. A small amount of hydrogen halide is introduced into the reaction system to effectively activate the propane, the selectivity of the propylene is more than 80 percent, a once through yield of the propylene is close to 50 percent, and performance of the propylene is much better than the performance of the traditional propylene which is obtained by directly dehydrogenizing and performing oxidative dehydrogenation on the propane; a reaction process is gentle, advanced oxidation for oxidative dehydrogenation of propane to prepare the propylene is greatly suppressed at the presence of halogen hydride, the selectivity of the propylene is greatly improved, and a problem of low selectivity of the propylene at high conversion rate of the propane is solved; and the hydrogen halide is recoverable and reused, energy consumption is low, the employed catalyst is a non-noble metal catalyst, and the components is remained stable during the reaction.
MgI2-Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies
Berthet, Mathéo,Davanier, Florian,Dujardin, Gilles,Martinez, Jean,Parrot, Isabelle
supporting information, p. 11014 - 11016 (2015/11/10)
The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports. Amazing MgI2: Protecting groups have had a tremendous positive impact on the art of biomolecule synthesis. In a context in which the use of attractive protecting groups is often limited by harsh deprotection conditions and low chemoselective flexibility, MgI2 offers, by the execution of a very simple protocol, a fresh vision with extensive perspectives.
Carbocations generated under stable conditions by ionization of matrix-isolated radicals: The allyl and benzyl cations
Misic, Vladimir,Piech, Krzysztof,Bally, Thomas
, p. 8625 - 8631 (2013/07/25)
Carbocations are crucial intermediates in many chemical reactions; hence, considerable effort has gone into investigating their structures and properties, for example, in superacids, in salts, or in the gas phase. However, studies of the vibrational structure of carbocations are not abundant, because their infrared spectra are difficult to obtain in superacids or salts (where furthermore the cations may be perturbed by counterions), and the generation of gas-phase carbocations in discharges usually produces several species. We have applied the technique of ionizing neutral compounds by X-irradiation of cryogenic Ar matrices to radicals embedded in such matrices, thus producing closed-shell cations that can be investigated leisurely, and in the absence of counterions or other perturbing effects, by various forms of spectroscopy. This Article describes the first set of results that were obtained by this approach, the IR spectra of the allyl and the benzyl cation. We use the information obtained in this way, together with previously obtained data, to assess the changes in chemical bonding between the allyl and benzyl radicals and cations, respectively.
Carbodeoxygenation of biomass: The carbonylation of glycerol and higher polyols to monocarboxylic acids
Coskun, Timur,Conifer, Christopher M.,Stevenson, Laura C.,Britovsek, George J. P.
supporting information, p. 6840 - 6844 (2013/07/05)
Glycerol is converted to a mixture of butyric and isobutyric acid by rhodium- or iridium-catalysed carbonylation using HI as the co-catalyst. The initial reaction of glycerol with HI results in several intermediates that lead to isopropyl iodide, which upon carbonylation forms butyric and isobutyric acid. At low HI concentration, the intermediate allyl iodide undergoes carbonylation to give vinyl acetic acid and crotonic acid. Higher polyols CnH n+2(OH)n are carbonylated to the corresponding C n+1 mono-carboxylic acids. Copyright
Highly enantioselective copper-catalyzed alkylation of β-ketoesters and subsequent cyclization to spirolactones/bi-spirolactones
Deng, Qing-Hai,Wadepohl, Hubert,Gade, Lutz H.
supporting information; experimental part, p. 2946 - 2949 (2012/03/26)
Cu-catalyzed enantioselective alkylation of β-ketoesters using alcohols for in situ preparation of alkylating reagents is reported. A number of functionalized β-ketoesters containing a quaternary carbon stereocenter are obtained with up to 99% ee. The alkylation products derived from 2-substituted allylic alcohols or their corresponding iodides can then be converted to spirolactones, bi-spirolactones, and related chiral target products.
PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS
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Page/Page column 6, (2011/04/24)
The present invention relates to a process for the preparation of compounds containing CF3O groups using compounds containing at least one group Y, in which Y=—Hal, —OSO2(CF2)zF, —OSO2CzH2z+1 (z=1-10), —OSO2F, —OSO2Cl, —OC(O)CF3— or —OSO2Ar, to a process for the preparation of compounds containing CF3O groups using KOCF3 and/or RbOCF3, and to novel compounds containing CF3O groups, and to the use thereof.
Microwave activation of alumina and its use as a catalyst in synthetic reactions
Dadush, Eric,Green, James F.,Sease, Aaron,Naravane, Abhijit,Pagni, Richard M.,Kabalka, George W.
experimental part, p. 120 - 123 (2010/02/28)
Microwave irradiation is a simple and efficient method of activating gamma alumina. Alumina activated in this manner is an excellent medium in which to carry out the Diels-Alder reaction and, in conjunction with additional microwave irradiation, the Claisen rearrangement. Several 2-allylphenols formed in the Claisen rearrangement rapidly undergo ring closure on alumina to form dihydrobenzofurans demonstrating the Br0nsted acidity of the solid.
