ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate

Base Information

• Chemical Name: ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate
• CAS No.: 859843-64-4
• Molecular Formula: C₂₁H₂₀N₂O₄
• Molecular Weight: 364.401
• Mol file: 859843-64-4.mol

Synonyms:ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate

Chemical Property of ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate

There total 5 articles about ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

ethyl 8-amino-6-methyl-2,3-dihydro-4H-1-benzopyran-2-carboxylate (859843-63-3) + 4-cyanobenzoyl chlorIde (6068-72-0) → ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate (859843-64-4)

Guidance literature:

With triethylamine; In dichloromethane; at -10 - 20 ℃; for 6h;

DOI:10.1081/SCC-200057984

Reference yield:

ethyl 4-(2-hydroxy-5-methyl-3-nitrophenyl)-2,4-dioxobutanoate (859843-60-0) → ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate (859843-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / glacial acetic acid; HCl / 2 h / 80 °C

2: 80 percent / HCl; hydrogen / palladium on activated charcoal / ethanol / 53 h / 50 - 60 °C / 5250.42 - 7500.6 Torr

3: 68 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

With hydrogenchloride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1081/SCC-200057984

Reference yield:

ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate (859843-61-1) → ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate (859843-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / HCl; hydrogen / palladium on activated charcoal / ethanol / 53 h / 50 - 60 °C / 5250.42 - 7500.6 Torr

2: 68 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1081/SCC-200057984

upstream raw materials:

ethyl 8-amino-6-methyl-2,3-dihydro-4H-1-benzopyran-2-carboxylate

4-cyanobenzoyl chlorIde

ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate

ethyl 4-(2-hydroxy-5-methyl-3-nitrophenyl)-2,4-dioxobutanoate

Downstream raw materials:

ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate