ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate

Base Information

Chemical Name:ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate
CAS No.:859843-66-6
Molecular Formula:C₂₂H₂₁N₃O₆
Molecular Weight:423.425
Hs Code.:

Synonyms:ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate

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Chemical Property of ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate

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Technology Process of ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate

There total 6 articles about ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 859843-64-4
ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate

: 541-41-3
chloroformic acid ethyl ester

: 859843-66-6
ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate

Guidance literature:: ethyl 8-[(4-cyanobenzoyl)amino]-6-methyl-2-chromanecarboxylate; With hydroxylamine; In ethanol; at 50 ℃;

chloroformic acid ethyl ester; With pyridine; at 120 ℃;
DOI:10.1081/SCC-200057984

Reference yield:

: 859843-60-0
ethyl 4-(2-hydroxy-5-methyl-3-nitrophenyl)-2,4-dioxobutanoate

: 859843-66-6
ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 81 percent / glacial acetic acid; HCl / 2 h / 80 °C

2.1: 80 percent / HCl; hydrogen / palladium on activated charcoal / ethanol / 53 h / 50 - 60 °C / 5250.42 - 7500.6 Torr

3.1: 68 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

4.1: hydroxylamine / ethanol / 50 °C

4.2: 67 percent / pyridine / 120 °C

With hydrogenchloride; hydrogen; hydroxylamine; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1081/SCC-200057984

Reference yield:

: 859843-61-1
ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate

: 859843-66-6
ethyl 6-methyl-8-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2-chromanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / HCl; hydrogen / palladium on activated charcoal / ethanol / 53 h / 50 - 60 °C / 5250.42 - 7500.6 Torr

2.1: 68 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

3.1: hydroxylamine / ethanol / 50 °C

3.2: 67 percent / pyridine / 120 °C

With hydrogenchloride; hydrogen; hydroxylamine; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1081/SCC-200057984