2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Name:2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1345404-00-3
Molecular Formula:C₂₆H₃₂N₄O₃S
Molecular Weight:480.631
Hs Code.:

Synonyms:2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 7 articles about 2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254069-38-9
3-(methylthio)-1-phenyl-1H-indazol-6-amine

: 149518-50-3
2-(1-(tert-butoxycarbonyl)-2-piperidinyl)acetic acid

: 1345404-00-3
2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 2-(1-(tert-butoxycarbonyl)-2-piperidinyl)acetic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 15 ℃; for 0.166667h; Inert atmosphere;

3-(methylthio)-1-phenyl-1H-indazol-6-amine; In dichloromethane; at 15 ℃; for 2h; Inert atmosphere;

Reference yield:

: 619-17-0
4-Nitroanthranilic acid

: 1345404-00-3
2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: ethanol / 0.08 h / Reflux

3.1: hydrogenchloride; sodium nitrite / ethanol; water; tetrahydrofuran / 1.67 h / 72 °C / Reflux

4.1: tetraphosphorus decasulfide / xylene / 0.67 h / Reflux

5.1: caesium carbonate / acetonitrile / 1 h / 10 °C

6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 0.8 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 0.17 h / 15 °C / Inert atmosphere

7.2: 2 h / 15 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; tetraphosphorus decasulfide; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; xylene;

Reference yield:

: 63480-10-4
4-nitroisatoic anhydride

: 1345404-00-3
2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 0.08 h / Reflux

2.1: hydrogenchloride; sodium nitrite / ethanol; water; tetrahydrofuran / 1.67 h / 72 °C / Reflux

3.1: tetraphosphorus decasulfide / xylene / 0.67 h / Reflux

4.1: caesium carbonate / acetonitrile / 1 h / 10 °C

5.1: hydrogen / palladium on activated charcoal / ethyl acetate / 0.8 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 0.17 h / 15 °C / Inert atmosphere

6.2: 2 h / 15 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; tetraphosphorus decasulfide; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; xylene;