1254069-38-9

Basic information

• Product Name: 1H-Indazol-6-amine, 3-(methylthio)-1-phenyl-
• Synonyms: 3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylamine
• CAS NO: 1254069-38-9
• Molecular Formula: C14H13N3S
• Molecular Weight: 255.343
• Mol File: 1254069-38-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indazol-6-amine, 3-(methylthio)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazol-6-amine, 3-(methylthio)-1-phenyl-(1254069-38-9)
• EPA Substance Registry System: 1H-Indazol-6-amine, 3-(methylthio)-1-phenyl-(1254069-38-9)

Safety Data

• Hazardous Substances Data: 1254069-38-9(Hazardous Substances Data)

Usage

Structure

1H-Indazol-6-amine, 3-(methylthio)-1-phenylis a derivative of 1H-indazole with a phenyl group substituted at the 1-position, a thiomethyl group at the 3-position, and an amine group at the 6-position.

Usage

Building block in organic synthesis, particularly in the pharmaceutical industry for the development of potential drug candidates.

Versatility

The compound's structure and functional groups make it a versatile intermediate for the synthesis of various bioactive molecules and potential pharmaceuticals.

Upstream product

• 619-17-0 4-Nitroanthranilic acid 
• 100-63-0 phenylhydrazine 
• 63480-10-4 4-nitroisatoic anhydride 
• 1254069-37-8 6-nitro-1-phenyl-1,2-dihydroindazol-3-thione 
• 1254069-39-0 6-nitro-1-phenyl-2,3-dihydro-1H-indazol-3-one 
• 67571-10-2 2-amino-4-nitro-N'-phenylbenzohydrazide 
• 1254069-40-3 3-(methylthio)-6-nitro-1-phenyl-1H-indazole 

Downstream Products

• 1254069-36-7 N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride 
• 1254069-41-4 4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester 
• 1345404-00-3 2-[(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1345403-98-6 3-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)-azetidine-1-carboxylic acid tert-butyl ester 
• 1332526-65-4 N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-3-carboxamide 
• 1332526-69-8 N-(3-methylsulfanyl-1-phenyl-1H-indazol-6-yl)-3-(piperazin-1-yl)propionamide 
• 1332526-67-6 N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)azetidine-3-carboxamide 
• 1332526-66-5 N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)pyrrolidine-3-carboxamide 
• 1345404-02-5 3-[3-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-ureido]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS

The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X.

Electron density guided fragment-based lead discovery of ketohexokinase inhibitors

A fragment-based drug design paradigm has been successfully applied in the discovery of lead series of ketohexokinase inhibitors. The paradigm consists of three iterations of design, synthesis, and X-ray crystallographic screening to progress low molecula