3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one

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Chemical Name:3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one
CAS No.:205055-05-6
Molecular Formula:C₂₀H₂₉IN₂O₆
Molecular Weight:520.365
Hs Code.:

Synonyms:3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one

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Chemical Property of 3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one

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Technology Process of 3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one

There total 5 articles about 3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92235-34-2
(2-oxopyrrolidin-3-(S)-yl)carbamic acid tert-butyl ester

: 205055-04-5
5-iodo-2-(2-methoxy-ethoxymethoxy)-benzyl bromide

: 205055-05-6
3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one

Guidance literature:: (2-oxopyrrolidin-3-(S)-yl)carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

5-iodo-2-(2-methoxy-ethoxymethoxy)-benzyl bromide; In tetrahydrofuran; at 0 ℃; for 4h;
DOI:10.1021/jm990041+

Reference yield:

: 1761-62-2
5-iodosalicyclaldehyde

: 205055-05-6
3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.08 h / 0 °C

1.2: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 0.75 h / 0 - 20 °C

2.1: NaBH₄ / tetrahydrofuran / 0.17 h / -15 °C

3.1: 69 percent / N-bromosuccinimide; Ph₃P / tetrahydrofuran / 0.5 h / 5 - 20 °C

4.1: NaH / tetrahydrofuran; dimethylformamide / 0.08 h / 0 °C

4.2: tetrahydrofuran / 4 h / 0 °C

With sodium tetrahydroborate; N-Bromosuccinimide; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Alkylation / 2.1: Reduction / 3.1: Bromination / 4.1: Metallation / 4.2: Substitution;
DOI:10.1021/jm990041+

Reference yield:

: 219671-66-6
5-iodo-2-(2-methoxy-ethoxymethoxy)-benzaldehyde

: 205055-05-6
3-(S)-(tert-butoxycarbonylamino)-1-(5-iodo-2-(2-methoxyethoxymethoxy)benzyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaBH₄ / tetrahydrofuran / 0.17 h / -15 °C

2.1: 69 percent / N-bromosuccinimide; Ph₃P / tetrahydrofuran / 0.5 h / 5 - 20 °C

3.1: NaH / tetrahydrofuran; dimethylformamide / 0.08 h / 0 °C

3.2: tetrahydrofuran / 4 h / 0 °C

With sodium tetrahydroborate; N-Bromosuccinimide; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: Bromination / 3.1: Metallation / 3.2: Substitution;
DOI:10.1021/jm990041+