(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol

Base Information

Chemical Name:(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol
CAS No.:1610667-03-2
Molecular Formula:C₁₄H₁₀F₃N₃O
Molecular Weight:293.248
Hs Code.:

Synonyms:(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol

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Chemical Property of (3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol

Chemical Property:

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Technology Process of (3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol

There total 4 articles about (3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607830-54-5
3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylic acid

: 1610667-03-2
(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol

Guidance literature:: 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at -10 ℃; for 0.166667h;

With sodium tetrahydroborate; In tetrahydrofuran; at -10 - 0 ℃;

Reference yield:

: 54013-06-8
ethyl 5-aminopyrazine-2-carboxylate

: 1610667-03-2
(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water; ethanol / 16 h / 90 °C

2.1: N-Bromosuccinimide / dichloromethane / 3 h / 20 °C

3.1: tris-(o-tolyl)phosphine; potassium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; toluene; methanol / 0.33 h / 110 °C / Microwave irradiation

3.2: 3 h / 20 °C

4.1: chloroformic acid ethyl ester; 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -10 °C

4.2: -10 - 0 °C

With 4-methyl-morpholine; potassium fluoride; N-Bromosuccinimide; chloroformic acid ethyl ester; sodium hydrogencarbonate; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 3.1: |Suzuki Coupling;

Reference yield:

: 588720-67-6
ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate

: 1610667-03-2
(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / dichloromethane / 3 h / 20 °C

2.1: tris-(o-tolyl)phosphine; potassium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; toluene; methanol / 0.33 h / 110 °C / Microwave irradiation

2.2: 3 h / 20 °C

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -10 °C

3.2: -10 - 0 °C

With 4-methyl-morpholine; potassium fluoride; N-Bromosuccinimide; chloroformic acid ethyl ester; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 2.1: |Suzuki Coupling;