9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

Base Information

Chemical Name:9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine
CAS No.:139870-53-4
Molecular Formula:C₂₅H₂₈ClN₅O₃
Molecular Weight:481.982
Hs Code.:

Synonyms:9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

Suppliers and Price of 9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

There total 7 articles about 9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 139870-49-8
1-O-mesyl-3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribitol

: 10310-21-1
2-Amino-6-chloropurin

: 139870-53-4
9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 16h;
DOI:10.1021/jm00086a015

Reference yield:

: 6160-50-5
3,5-di-O-benzyl-2-deoxy-D-ribofuranose

: 139870-53-4
9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium borohydride / ethanol / 0.5 h / 0 °C

2: 67 percent / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

3: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 2 h

4: 82 percent / p-TsOH / CH₂Cl₂; methanol / 0.5 h / Ambient temperature

5: triethylamine / CH₂Cl₂ / 1 h / 0 °C

6: 46 percent / K₂CO₃ / dimethylformamide / 16 h / 90 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00086a015

Reference yield:

: 132487-16-2
methyl 3,5-di-O-benzyl-2-deoxy-D-ribofuranoside

: 139870-53-4
9-(3,5-di-O-benzyl-4-O-methyl-2-deoxy-D-ribityl)-2-amino-6-chloropurine

Guidance literature:: Multi-step reaction with 7 steps

1: aq. acetic acid / 0.5 h / 100 °C

2: sodium borohydride / ethanol / 0.5 h / 0 °C

3: 67 percent / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

4: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 2 h

5: 82 percent / p-TsOH / CH₂Cl₂; methanol / 0.5 h / Ambient temperature

6: triethylamine / CH₂Cl₂ / 1 h / 0 °C

7: 46 percent / K₂CO₃ / dimethylformamide / 16 h / 90 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00086a015