tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate
CAS No.:1187214-07-8
Molecular Formula:C₃₀H₃₅FN₆O₅S
Molecular Weight:610.71
Hs Code.:

Synonyms:tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

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Chemical Property of tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

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Technology Process of tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

There total 11 articles about tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1127329-25-2
tert-butyl (2-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

: 765-30-0
Cyclopropylamine

: 1187214-07-8
tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

Guidance literature:: bis(trichloromethyl) carbonate; tert-butyl (2-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate; With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 1h;

Cyclopropylamine; at 20 ℃;

Reference yield:

: 39021-62-0
1-methylimidazole-5-carbaldehyde

: 1187214-07-8
tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: camphor-10-sulfonic acid / toluene / 24 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.33 h / -78 °C

2.2: -78 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C

3.2: -78 - 20 °C

3.3: 4 h / Reflux; Inert atmosphere

4.1: sodium hydrogencarbonate / diphenylether / 4 h / 180 °C

5.1: camphor-10-sulfonic acid / 5 h / Reflux

6.1: hydrogenchloride; water / acetone / 20 °C

7.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 24 h / 20 °C

8.1: dichloromethane / 20 °C

9.1: ammonium chloride; zinc / methanol; water / 24 h / Reflux

10.1: N-ethyl-N,N-diisopropylamine / 1 h / 20 °C

10.2: 20 °C

With hydrogenchloride; n-butyllithium; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; hexanes; diphenylether; dichloromethane; water; acetone; toluene;

Reference yield:

: 1127329-18-3
5-(1,3-dioxan-2-yl)-2-iodo-1-methyl-1H-imidazole

: 1187214-07-8
tert-butyl (2-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C

1.2: -78 - 20 °C

1.3: 4 h / Reflux; Inert atmosphere

2.1: sodium hydrogencarbonate / diphenylether / 4 h / 180 °C

3.1: camphor-10-sulfonic acid / 5 h / Reflux

4.1: hydrogenchloride; water / acetone / 20 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 24 h / 20 °C

6.1: dichloromethane / 20 °C

7.1: ammonium chloride; zinc / methanol; water / 24 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine / 1 h / 20 °C

8.2: 20 °C

With hydrogenchloride; n-butyllithium; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; hexanes; diphenylether; dichloromethane; water; acetone;