benzyl chloropurine(Boc) acetate

Base Information

• Chemical Name: benzyl chloropurine(Boc) acetate
• CAS No.: 1052677-01-6
• Molecular Formula: C₁₉H₂₀ClN₅O₄
• Molecular Weight: 417.852
• Mol file: 1052677-01-6.mol

Synonyms:benzyl chloropurine(Boc) acetate

Chemical Property of benzyl chloropurine(Boc) acetate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl chloropurine(Boc) acetate

There total 1 articles about benzyl chloropurine(Boc) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bis(trichloromethyl) carbonate (32315-10-9) + tert-butyl alcohol (75-65-0) + benzyl 2-amino-6-chloropurine-9-acetate (169287-67-6) → benzyl chloropurine(Boc) acetate (1052677-01-6)

Guidance literature:

bis(trichloromethyl) carbonate; benzyl 2-amino-6-chloropurine-9-acetate; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

tert-butyl alcohol; In tetrahydrofuran; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200800141

Reference yield: 76.0%

benzyl chloropurine(Boc) acetate (1052677-01-6) → [N2-(tert-butoxycarbonyl)guanidin-9-yl]acetic acid (1028077-12-4)

Guidance literature:

With sodium hydride; 3-Hydroxypropionitrile; In tetrahydrofuran; mineral oil; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200800141

upstream raw materials:

bis(trichloromethyl) carbonate

tert-butyl alcohol

benzyl 2-amino-6-chloropurine-9-acetate

Downstream raw materials:

[N²-(tert-butoxycarbonyl)guanidin-9-yl]acetic acid

Refernces