Technology Process of 3-([1,1'-biphenyl]-3-yl)-1-chloro-6,7-dimethoxyisoquinoline
There total 7 articles about 3-([1,1'-biphenyl]-3-yl)-1-chloro-6,7-dimethoxyisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trichlorophosphate;
at 110 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 1.5 h / 100 °C
2: trichlorophosphate / 3 h / 110 °C
With
potassium carbonate; trichlorophosphate;
palladium diacetate; XPhos;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride; n-Butyl nitrite / water; methanol / 2.5 h / 40 °C
2.1: sodium hydroxide; p-toluenesulfonyl chloride / water / 0.25 h / 50 - 80 °C
2.2: pH 3 - 4
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere
4.1: hydrogen bromide / diethyl ether / 2 h
5.1: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 1.5 h / 100 °C
6.1: trichlorophosphate / 3 h / 110 °C
With
hydrogenchloride; oxalyl dichloride; n-Butyl nitrite; hydrogen bromide; potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide; trichlorophosphate;
palladium diacetate; N,N-dimethyl-formamide; XPhos;
In
methanol; diethyl ether; dichloromethane; water; acetonitrile;