1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea

Base Information

• Chemical Name: 1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea
• CAS No.: 611168-85-5
• Molecular Formula: C₃₀H₃₄N₆O₅
• Molecular Weight: 558.637
• Mol file: 611168-85-5.mol

Synonyms:1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea

Chemical Property of 1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea

There total 3 articles about 1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C16H17Cl3N4O4 (1012883-12-3) + C16H20N2O2*ClH (317806-89-6,285984-50-1) → 1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea (611168-85-5)

Guidance literature:

C₁₆H₂₀N₂O₂*ClH; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

C₁₆H₁₇Cl₃N₄O₄; In dimethyl sulfoxide; at 60 ℃; for 9h;

DOI:10.1021/jm500167q

Reference yield: 64.0%

4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylamine (317806-90-9) + [5-tert-butyl-2-(3-nitrophenyl)-2H-pyrazol-3-yl]-carbamic acid phenyl ester (611168-84-4) → 1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea (611168-85-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 48h;

DOI:10.1021/jm030121k

Reference yield:

2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl-amine (476637-05-5) → 1-[2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]-urea (611168-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / pyridine / tetrahydrofuran / 20 °C

2: 64 percent / DIPEA / dimethylsulfoxide / 48 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm030121k

upstream raw materials:

4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylamine

[5-tert-butyl-2-(3-nitrophenyl)-2H-pyrazol-3-yl]-carbamic acid phenyl ester

2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl-amine

C₁₆H₁₇Cl₃N₄O₄

Downstream raw materials:

1-(3-(tert-butyl)-1-(3-((2-ethoxyethyl)amino)phenyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea