4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid

Base Information

Chemical Name:4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid
CAS No.:1447760-20-4
Molecular Formula:C₁₈H₂₃N₃O₁₃
Molecular Weight:489.393
Hs Code.:

Synonyms:4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid

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Chemical Property of 4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid

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Technology Process of 4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid

There total 4 articles about 4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1447760-18-0
[2-(2,3-bisnitrooxypropoxy)-5-formylphenyl] 3-(tert-butoxycarbonylamino)propanoate

: 1447760-20-4
4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid

Guidance literature:: With potassium permanganate; In acetone; at 0 - 20 ℃; for 1h;
DOI:10.1002/cmdc.201300105

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1447760-20-4
4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / acetonitrile / 4 h / 70 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: silver nitrate; iodine / acetonitrile / 17 h / -15 - 70 °C

4.1: potassium permanganate / acetone / 1 h / 0 - 20 °C

With dmap; potassium permanganate; iodine; potassium hydrogencarbonate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone; acetonitrile;
DOI:10.1002/cmdc.201300105

Reference yield:

: 79822-65-4
3-hydroxy-4-(2-propenyloxy)benzaldehyde

: 1447760-20-4
4-(2,3-bisnitrooxypropoxy)-3-[3-(tert-butoxycarbonylamino)propanoyloxy]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: silver nitrate; iodine / acetonitrile / 17 h / -15 - 70 °C

3.1: potassium permanganate / acetone / 1 h / 0 - 20 °C

With dmap; potassium permanganate; iodine; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone; acetonitrile;
DOI:10.1002/cmdc.201300105