o-Bromo-α,α-dimethylbenzyl chloride

Base Information

• Chemical Name: o-Bromo-α,α-dimethylbenzyl chloride
• CAS No.: 7073-71-4
• Molecular Formula: C₉H₁₀BrCl
• Molecular Weight: 233.535
• Mol file: 7073-71-4.mol

Synonyms:o-Bromo-α,α-dimethylbenzyl chloride

Chemical Property of o-Bromo-α,α-dimethylbenzyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Bromo-α,α-dimethylbenzyl chloride

There total 1 articles about o-Bromo-α,α-dimethylbenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-(2-bromophenyl)propanol (7073-69-0) → o-Bromo-α,α-dimethylbenzyl chloride (7073-71-4)

Guidance literature:

With hydrogenchloride; at 0 ℃; for 5.5h;

DOI:10.1021/jo00336a043

Reference yield: 73.0%

o-Bromo-α,α-dimethylbenzyl chloride (7073-71-4) → cumenyl chloride (934-53-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -100 ℃; for 1h;

DOI:10.1021/jo00336a043

Reference yield:

o-Bromo-α,α-dimethylbenzyl chloride (7073-71-4) → N-(4-methylpentane-2-yl)-N'-[2-(2-phenylpropane-2-yl)]benzene

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / 1 h

2: 1.8 g / sodium tert-butoxide; dppf / Pd(dppf)Cl₂ / toluene / 8 h / Heating

With 1,1'-bis-(diphenylphosphino)ferrocene; aluminium trichloride; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In toluene; 1: Friedel-Crafts alkylation / 2: Buchwald amination;

DOI:10.1081/SCC-200032408

upstream raw materials:

2-(2-bromophenyl)propanol

Downstream raw materials:

cumenyl chloride

2-phenyl-3,3-dimethylisoindoline-1-one

Refernces