7073-69-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Bromophenyl)-2-propanol is utilized as an intermediate in the synthesis of various drugs, contributing to the development of new medications and therapeutic agents. Its unique structure and reactivity make it a valuable component in the creation of complex organic molecules with potential medicinal properties.
Used in Chemical Industry:
In the chemical industry, 2-(2-Bromophenyl)-2-propanol is employed as a chiral building block for the synthesis of complex organic molecules. Its enantiomeric forms offer distinct properties that can be leveraged in the design and production of specialty chemicals, fine chemicals, and other high-value compounds.
Overall, 2-(2-Bromophenyl)-2-propanol's applications in both the pharmaceutical and chemical industries underscore its importance as a versatile and essential compound in the synthesis and development of a wide array of products.

InChI:InChI=1/C9H11BrO/c1-9(2,11)7-5-3-4-6-8(7)10/h3-6,11H,1-2H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 75-16-1 methylmagnesium bromide 
• 676-58-4 methylmagnesium chloride 
• 7154-66-7 2-bromobenzoic acid chloride 
• 2142-69-0 2-bromophenyl methyl ketone 
• 74-88-4 methyl iodide 
• 5411-56-3 1-(2-bromophenyl)ethanol 
• 6630-33-7 ortho-bromobenzaldehyde 
• 88-65-3 2-bromobenzoic-acid 
• 67-64-1 acetone 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 7073-71-4 o-Bromo-α,α-dimethylbenzyl chloride 
• 59043-48-0 1-[2-(1-hydroxy-1-methylethyl)phenyl]cyclohexanol 
• 78175-94-7 1-phenyl-3,3-dimethyl-3H-2,1-benzoxaphosphole 
• 68823-66-5 1-(2-isopropenyl-phenyl)-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaphosphole 1-oxide 
• 67771-45-3 2-[2-(3,3-dimethyl-1-oxo-1,3-dihydro-1λ⁵-benzo[c][1,2]oxaphosphol-1-yl)-phenyl]-propan-2-ol 
• 71401-78-0 3,3-dimethyl-1-oxo-1,3-dihydro-1λ⁵-benzo[c][1,2]oxaphosphol-1-ol 
• 82123-47-5 benzyl-1-(2-bromophenyl)-1-methylethyl ether 
• 96897-83-5 isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether 
• 134024-27-4 1-Bromo-2-(1-methoxy-1-methyl-ethyl)-benzene 
• 7073-70-3 1-bromo-2-isopropenylbenzene 
• 221352-10-9 3,3-dimethylbenzo [c][1,2]oxaborol-1(3H)-ol 
• 141754-15-6 1-bromo-2-(3-bromoprop-1-en-2-yl)benzene 
• 141754-16-7 (1R,5S)-3-[2-(2-Bromo-phenyl)-allyl]-4,6,6-trimethyl-bicyclo[3.1.1]hept-3-en-2-one 
• 78175-97-0 methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide 

Relevant academic research and scientific papers

Synthesis method of montelukast sodium intermediate

The invention is applicable to the technical field of medicine synthesis, and provides a synthesis method of a montelukast sodium intermediate. The method comprises the following steps of: generatinga compound II from halogenated benzene under the action

Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides

Several boron-containing small molecules have been approved by the US FDA to treat human diseases. We explored potential applications of boron-containing compounds in modern agriculture by pursuing multiple research and development programs. Here, we report a novel series of multi-substitution benzoxaboroles (1–36), a compound class that we recently reported as targeting geranylgeranyl transferase I (GGTase I) and thereby inhibiting protein prenylation (Kim et al., 2020). These compounds were designed, synthesized, and tested against the agriculturally important fungal pathogens Mycosphaerella fijiensis and Colletotrichum sublineolum in a structure–activity relationship (SAR) study. Compounds 13, 28, 30, 34 and 36 were identified as active leads with excellent antifungal MIC95 values in the range of 1.56–3.13 ppm against M. fijiensis and 0.78–3.13 ppm against C. sublineolum.

BORON CONTAINING COMPOUNDS AND THEIR USES

The present disclosure contemplates novel boron-containing compounds and their uses as active agents that exhibit pesticidal activity such as antimicrobial, insecticidal, arachnicidal, and/or anti parasitic activity. An agrochemical composition containing such a compound and its use in, animal health, agriculture, or horticulture is also contemplated. A method for promoting plant performance and/or controlling, reducing, preventing, ameliorating, or inhibiting microbes, insects, arachnids, and/or parasites on or in an animal, a plant, a plant part, plant propagation material, and/or harvested fruits or vegetables is also contemplated.

Benzoxaborole Catalyst for Site-Selective Modification of Polyols

The site-selective modification of polyols bearing several hydroxyl groups without the use of protecting groups remains a significant challenge in synthetic chemistry. To address this problem, novel benzoxaborole derivatives were designed as efficient catalysts for the highly site-selective and protecting-group-free modification of polyols. To identify the effective substituent groups enhancing the catalytic activity and selectivity, a series of benzoxaborole catalysts 1a–k were synthesized. In-depth analysis for the substituent effect revealed that 1i–k, bearing multiple electron-withdrawing fluoro- and trifluoromethyl groups, exhibited the greatest catalytic activity and selectivity. Moreover, 1i-catalyzed benzoylation, tosylation, benzylation, and glycosylation of various cis-1,2-diol derivatives proceeded with good yield and site-selective manner.

Rh-Catalyzed Asymmetric Hydrogenation of α,β- and β,β-Disubstituted Unsaturated Boronate Esters

A highly enantioselective hydrogenation of α,β-unsaturated boronate esters catalyzed by Rh-(S)-DTBM-Segphos complex has been developed. Both (Z)-α,β- and β,β-disubstituted substrates can be successfully hydrogenated to afford chiral boronates with excellent enantioselectivities, up to 98 % ee. Furthermore, the obtained chiral boronate esters, as important versatile synthetic intermediates are successfully transformed to the corresponding chiral alcohols, amines and other important derivatives with maintained enantioselectivities.

Spatial anion control on palladium for mild C-H arylation of arenes

C-H arylation of arenes without the use of directing groups is a challenge, even for simple molecules, such as benzene. We describe spatial anion control as a concept for the design of catalytic sites for C-H bond activation, thereby enabling nondirected C-H arylation of arenes at ambient temperature. The mild conditions enable late-stage structural diversification of biologically relevant small molecules, and site-selectivity complementary to that obtained with other methods of arene functionalization can be achieved. These results reveal the potential of spatial anion control in transition-metal catalysis for the functionalization of C-H bonds under mild conditions.

Unexpected reactivity of cyclic perfluorinated iodanes with electrophiles

We have found that cyclic perfluorinated iodanes react with electrophiles (E+ = Br, Cl, F, I) to afford perfluorinated E-RF compounds. This reactivity is unexpected since cyclic perfluorinated iodanes are considered as electrophilic reagents that normally react with nucleophiles (e.g. Nu- = SR, OR) to afford Nu-RF products. The utility of this new transformation is demonstrated for a [18F]CF3CF2-containing compound which was prepared from [18F]XeF2 obtained from cyclotron produced [18F]fluoride.

SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

Compounds of the menthane series. Synthesis of unsaturated primary alcohols with the o- and p-menthane skeletons

Precursors to terpene alcohols of the o- and p-menthane series (o-cimen-7-ol and o- and p-cimen-9-ols) were synthesized, and their reduction with lithium in ethylenediamine was studied. The reduction of o- and p-cimen-9-ols in the presence of isopropyl alcohol selectively afforded the corresponding 1,4-dihydro derivatives. Under analogous conditions, o-cimen-7-ol was converted into a mixture of unsaturated hydrocarbons. The reduction with lithium in ethylenediamine in the absence of isopropyl alcohol in all cases gave mixtures of menthene alcohols.

An enantioselective formal synthesis of montelukast sodium

A formal synthesis of the antiasthma drug montelukast sodium is described, wherein the key chiral diol intermediate was accessed with greater convergence of the C-C bond-forming steps as compared to previous routes. Improved synthetic efficiency was achie