3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide

Base Information

Chemical Name:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide
CAS No.:921629-84-7
Molecular Formula:C₃₂H₃₉Cl₂N₃O₅
Molecular Weight:616.585
Hs Code.:

Synonyms:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide

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Chemical Property of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide

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Technology Process of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide

There total 16 articles about 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 921629-84-7
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

2: 0.5 h / 150 °C / Microwave irradiation

3: sodium carbonate / triphenylphosphine; palladium(II) bromide / water; N,N-dimethyl-formamide / 7 h / 100 °C

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h

5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 70 °C

6: sodium hydride; ethanethiol / N,N-dimethyl-formamide / 1.5 h / 0 - 150 °C

7: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

9: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; ethanethiol; palladium 10% on activated carbon; triphenylphosphine; palladium(II) bromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1056555-31-7
tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

: 921629-84-7
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

Reference yield:

: N-cyclopropyl-2-methoxy-6-[(1E)-3-methoxyprop-1-en-1-yl]isonicotinamide

: 921629-84-7
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{[2-hydroxy-6-(3-methoxypropyl)pyridin-4-yl]methyl}propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 70 °C

3: sodium hydride; ethanethiol / N,N-dimethyl-formamide / 1.5 h / 0 - 150 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

6: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; ethanethiol; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;