tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Base Information

Chemical Name:tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate
CAS No.:1056555-31-7
Molecular Formula:C₄₃H₆₁Cl₂N₃O₇Si
Molecular Weight:830.965
Hs Code.:

tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Synonyms:tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

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Chemical Property of tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

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Technology Process of tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

There total 15 articles about tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1056555-31-7
tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

2: 0.5 h / 150 °C / Microwave irradiation

3: sodium carbonate / triphenylphosphine; palladium(II) bromide / water; N,N-dimethyl-formamide / 7 h / 100 °C

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h

5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 70 °C

6: sodium hydride; ethanethiol / N,N-dimethyl-formamide / 1.5 h / 0 - 150 °C

7: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; ethanethiol; palladium 10% on activated carbon; triphenylphosphine; palladium(II) bromide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 921630-54-8
N-{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}cyclopropanamine

: 1056555-04-4
3-[(tert-butoxycarbonyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoic acid

: 1056555-31-7
tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: N-cyclopropyl-2-methoxy-6-[(1E)-3-methoxyprop-1-en-1-yl]isonicotinamide

: 1056555-31-7
tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 70 °C

3: sodium hydride; ethanethiol / N,N-dimethyl-formamide / 1.5 h / 0 - 150 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; ethanethiol; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;