<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

Base Information

Chemical Name:<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate
CAS No.:170700-78-4
Molecular Formula:C₄₂H₄₉N₅O₁₂
Molecular Weight:815.877
Hs Code.:

<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis<N-(benzyloxy)carbonyl>-L-valinate

Synonyms:<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

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Chemical Property of <(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

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Technology Process of <(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

There total 5 articles about <(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 178614-85-2,158257-41-1
N-CBZ-L-Val NCA

: 2-<(((4-benzyloxy)carbonyl)amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediol sodium salt

: 170700-78-4
<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

Guidance literature:: In N,N-dimethyl-formamide; for 3.5h; Ambient temperature;
DOI:10.1080/15257779508009494

Reference yield: 82.0%

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 2-<(((4-benzyloxy)carbonyl)amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediol sodium salt

: 170700-78-4
<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 5 ℃; for 1h;
DOI:10.1080/15257779508009494

Reference yield:

: 103824-50-6
2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyloxy>-1,3-propanediyl dibenzoate

: 170700-78-4
<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaHCO₃ / H₂O / 24 h / Ambient temperature

2: 96 percent / aq. NaOH / methanol; tetrahydrofuran / 0.5 h

3: 82 percent / DCC, DMAP / tetrahydrofuran / 1 h / 5 °C

With dmap; sodium hydroxide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; water;
DOI:10.1080/15257779508009494