103824-50-6

Basic information

• Product Name: 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyloxy>-1,3-propanediyl dibenzoate
• Synonyms: 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyloxy>-1,3-propanediyl dibenzoate
• CAS NO: 103824-50-6
• Molecular Weight: 423.425
• Mol File: 103824-50-6.mol

Chemical Properties

• CAS DataBase Reference: 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyloxy>-1,3-propanediyl dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyloxy>-1,3-propanediyl dibenzoate(103824-50-6)
• EPA Substance Registry System: 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyloxy>-1,3-propanediyl dibenzoate(103824-50-6)

Safety Data

• Hazardous Substances Data: 103824-50-6(Hazardous Substances Data)

Upstream product

• 71-30-7 Cytosine 
• 110874-22-1 2-(acetoxymethoxy)-1,3-propanediyl dibenzoate 
• 110874-21-0 2-(methoxymethoxy)-1,3-propanediyl dibenzoate 
• 103824-47-1 2-(bromomethoxy)propane-1,3-diyl dibenzoate 
• 18037-10-0 2,4-O,N-bis(trimethylsilyl)cytosine 

Downstream Products

• 130914-74-8 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate 
• 170700-78-4 <(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate 
• 170700-76-2 2-<(4-(((benzyloxy)carbonyl)amino)-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl dibenzoate 

Relevant articles and documents

Effect of various pyrimidines possessing the 1-[(2-hydroxy-1- (hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2′- deoxyribose, on wild-type and mutant hepatitis B virus replication

Hepatitis B virus (HBV) is the most common cause of chronic liver disease worldwide. Development of drug resistance against clinical anti-HBV drug lamivudine due to long-term use and rebound of viral DNA after cessation of treatment has been a major setba

An efficient synthesis of 2-[(4-amino-1,2-dihydro-2-oxo-1- pyrimidinyl)methoxy]-1,3-propanediyl-di-L-valinate an anti-cytomegalovirus agent

An efficient synthesis for large scale preparation of the titled compound, a prodrug for the anti-HCMV agent 1-[2-hydroxy-1- (hydroxymethyl)ethoxy)methyl]cytosine, 9, has been developed. The product of each step is easily purified by either distillation o

EFFICIENT SYNTHESIS OF 1,2-seco AND 1,2-seco 2-nor PYRIMIDINE AND PURINE NUCLEOSIDES.

Unprotected sylilated purines and pyrimidines (adenine, guanine, cytosine, thymine) reacted with acetoxymethyl ether (acyclic sugar analogues) under solid PTC conditions, using KI and dibenzo-18-crown-6 in benzene-acetonitrile(1:1, v/v) to give regiospecifically the corresponding N-9 purine and N-1 pyrimidine acyclic nucleosides in fairly good yields.