sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate

Base Information

Chemical Name:sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate
CAS No.:1428127-99-4
Molecular Formula:C₂₂H₁₄ClF₂N₂O₃*Na
Molecular Weight:450.804
Hs Code.:

Synonyms:sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate

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Chemical Property of sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate

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Technology Process of sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate

There total 7 articles about sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1428130-12-4
1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid

: 1428127-99-4
sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate

Guidance literature:: With sodium t-butanolate; In methanol; at 20 ℃; for 2h;

Reference yield:

: 632625-91-3
1-(bromomethyl)-2,4-difluorobenzene

: 1428127-99-4
sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 0 °C

2.1: phosphorus tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 16 h / 0 °C

4.1: sodium hydroxide / ethanol; water / 90 °C

5.1: sodium t-butanolate / methanol / 2 h / 20 °C

With sodium tetrahydroborate; phosphorus tribromide; sodium hydride; sodium hydroxide; sodium t-butanolate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1428130-10-2
1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carbonitrile

: 1428127-99-4
sodium 1-(5-chloro-2-((2,4-difluorobenzyl)oxy)benzyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 90 °C

2: sodium t-butanolate / methanol / 2 h / 20 °C

With sodium hydroxide; sodium t-butanolate; In methanol; ethanol; water;