JD-5037

Base Information

Chemical Name:JD-5037
CAS No.:1392116-14-1
Molecular Formula:C₂₇H₂₇Cl₂N₅O₃S
Molecular Weight:572.515
Hs Code.:
Mol file:1392116-14-1.mol

Synonyms:(S)-2-((S)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Suppliers and Price of JD-5037

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
JD5037
5mg
$ 205.00

DC Chemicals
JD5037 >95%
100 mg
$ 700.00

DC Chemicals
JD5037 >95%
1 g
$ 2700.00

ChemScene
JD-5037 98.77%
100mg
$ 1380.00

ChemScene
JD-5037 98.77%
50mg
$ 768.00

ApexBio Technology
JD5037
5mg
$ 162.00

Ambeed
(S)-2-((((S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide 98+%
1g
$ 1590.00

Ambeed
(S)-2-((((S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide 98+%
25mg
$ 189.00

Ambeed
(S)-2-((((S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide 98+%
250mg
$ 635.00

Ambeed
(S)-2-((((S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide 98+%
100mg
$ 320.00

Total 15 raw suppliers

Chemical Property of JD-5037

Chemical Property:

Boiling Point:721.6±70.0 °C(Predicted)
PKA:10.63±0.60(Predicted)
Density:1.40±0.1 g/cm3(Predicted)
Solubility.:≥143.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Purity/Quality:

99%, ^*data from raw suppliers

JD5037 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses JD 5037 is an anti-obesity drug candidate which acts as a peripherally-cannabinoid inverse agonist. Acts on the CB1 receptors.

Technology Process of JD-5037

There total 3 articles about JD-5037 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₆Cl₂N₄O₄S

: 1392116-14-1
(S)-2-((S)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

: 1404117-65-2
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Guidance literature:: C₂₇H₂₆Cl₂N₄O₄S; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -10 ℃; for 0.5h;

With ammonia; In tetrahydrofuran; dichloromethane; at -5 - 20 ℃; for 3.5h; Overall yield = 50 %; Overall yield = 9.745 g;

Reference yield:

: 464213-17-0
3-(4-chlorophenyl)-N-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide

: 1392116-14-1
(S)-2-((S)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

: 1404117-65-2
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentachloride / chlorobenzene / 1.5 h / Reflux

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: lithium hydroxide / water; tetrahydrofuran / 14 h / 15 °C

3.2: pH Ca_. 1 - 2

4.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / -10 °C

4.2: 3.5 h / -5 - 20 °C

With 4-methyl-morpholine; phosphorus pentachloride; triethylamine; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; chlorobenzene;

Reference yield:

: 362519-51-5
4-Chloro-N-[1-chloro-1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-meth-(E)-ylidene]-benzenesulfonamide

: 1392116-14-1
(S)-2-((S)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

: 1404117-65-2
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

2.1: lithium hydroxide / water; tetrahydrofuran / 14 h / 15 °C

2.2: pH Ca_. 1 - 2

3.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / -10 °C

3.2: 3.5 h / -5 - 20 °C

With 4-methyl-morpholine; triethylamine; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water;