(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Base Information

Chemical Name:(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide
CAS No.:1404117-65-2
Molecular Formula:C₂₇H₂₇Cl₂N₅O₃S
Molecular Weight:572.515
Hs Code.:

Synonyms:(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of (S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

There total 3 articles about (S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₆Cl₂N₄O₄S

: 1392116-14-1
(S)-2-((S)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

: 1404117-65-2
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Guidance literature:: C₂₇H₂₆Cl₂N₄O₄S; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -10 ℃; for 0.5h;

With ammonia; In tetrahydrofuran; dichloromethane; at -5 - 20 ℃; for 3.5h; Overall yield = 50 %; Overall yield = 9.745 g;

Reference yield:

: 464213-17-0
3-(4-chlorophenyl)-N-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide

: 1392116-14-1
(S)-2-((S)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

: 1404117-65-2
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentachloride / chlorobenzene / 1.5 h / Reflux

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: lithium hydroxide / water; tetrahydrofuran / 14 h / 15 °C

3.2: pH Ca_. 1 - 2

4.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / -10 °C

4.2: 3.5 h / -5 - 20 °C

With 4-methyl-morpholine; phosphorus pentachloride; triethylamine; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; chlorobenzene;

Reference yield:

: 362519-51-5
4-Chloro-N-[1-chloro-1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-meth-(E)-ylidene]-benzenesulfonamide

: 1392116-14-1
(S)-2-((S)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

: 1404117-65-2
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

2.1: lithium hydroxide / water; tetrahydrofuran / 14 h / 15 °C

2.2: pH Ca_. 1 - 2

3.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / -10 °C

3.2: 3.5 h / -5 - 20 °C

With 4-methyl-morpholine; triethylamine; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water;