3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

Base Information

Chemical Name:3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide
CAS No.:912962-93-7
Molecular Formula:C₂₇H₃₁N₃O₃S₂
Molecular Weight:509.693
Hs Code.:

Synonyms:3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

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Chemical Property of 3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

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Technology Process of 3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

There total 2 articles about 3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 912962-92-6
2-(benzimidazol-1-yl)-1-(3-bromophenyl)ethanone

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 912962-93-7
3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm2015099

Reference yield:

: 51-17-2,79351-71-6
benzoimidazole

: 18523-22-3
2,3'-dibromoacetophenone

: 912962-93-7
3-[3-(2-(benzimidazol-1-yl)acetyl)phenyl]-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 1 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 4 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; ethanol; water; toluene; 2: Suzuki coupling;
DOI:10.1021/jm2015099