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18523-22-3

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18523-22-3 Usage

Chemical Properties

light yellow crystalline powder

Uses

Different sources of media describe the Uses of 18523-22-3 differently. You can refer to the following data:
1. It is employed as an intermediate for pharmaceutical and organic synthesis.
2. 3-Bromophenacyl bromide is a useful intermediate for pharmaceutical and organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 18523-22-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,5,2 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 18523-22:
(7*1)+(6*8)+(5*5)+(4*2)+(3*3)+(2*2)+(1*2)=103
103 % 10 = 3
So 18523-22-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H6Br2O/c9-5-8(11)6-2-1-3-7(10)4-6/h1-4H,5H2

18523-22-3 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (A15210)  2,3'-Dibromoacetophenone, 97%   

  • 18523-22-3

  • 1g

  • 284.0CNY

  • Detail
  • Alfa Aesar

  • (A15210)  2,3'-Dibromoacetophenone, 97%   

  • 18523-22-3

  • 5g

  • 837.0CNY

  • Detail
  • Alfa Aesar

  • (A15210)  2,3'-Dibromoacetophenone, 97%   

  • 18523-22-3

  • 25g

  • 3619.0CNY

  • Detail

18523-22-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-1-(3-bromophenyl)ethanone

1.2 Other means of identification

Product number -
Other names a,3'-dibromoacetophenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18523-22-3 SDS

18523-22-3Relevant articles and documents

Thiazole ring-containing amide compounds as well as preparation method and application thereof

-

Paragraph 0044; 0051; 0078; 0081; 0157; 0162; 0241; 0246, (2021/06/23)

The invention discloses thiazole ring-containing amide compounds as well as a preparation method and application thereof, and belongs to the field of chemical technologies and pesticides. According to the present invention, p-phenylenediamine is adopted as a raw material to synthesize a series of the thiazole ring-containing amide compounds, and the synthesized thiazole ring-containing amide compounds have good inhibition effects on Xanthomonas oryzae pv.Oryza (Xoo), Xanthomonas oryzae pv.Oryzcola (Xoc) and Xanthomonas axonophora pv.Citri (Xac) in agricultural diseases and insect pests, and can be used for preparing the anti-plant bacterium agent.

Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies

Zhou, You,Lu, Xin,Du, Chenxi,Liu, Yijun,Wang, Yifan,Hong, Kwon Ho,Chen, Yao,Sun, Haopeng

, (2021/01/07)

In our effort towards the identification of novel BuChE-IDO1 dual-targeted inhibitor for the treatment of Alzheimer's disease (AD), sertaconazole was identified through a combination of structure-based virtual screening followed by MM-GBSA rescoring. Preliminary chemical optimization was performed to develop more potent and selective sertaconazole analogues. In consideration of the selectivity and the inhibitory activity against target proteins, compounds 5c and 5d were selected for the next study. Further modification of compound 5c led to the generation of compound 10g with notably improved selectivity towards BuChE versus AChE. The present study provided us with a good starting point to further design potent and selective BuChE-IDO1 inhibitors, which may benefit the treatment of late stage AD.

An umpolung oxa-[2,3] sigmatropic rearrangement employing arynes for the synthesis of functionalized enol ethers

Gaykar, Rahul N.,George, Malini,Guin, Avishek,Bhattacharjee, Subrata,Biju, Akkattu T.

supporting information, p. 3447 - 3452 (2021/05/04)

An oxa-[2,3] sigmatropic rearrangement involving arynes is reported featuring the umpolung of ketones, where the C=O bond polarity is reversed. The in situ-generated sulfur ylides from β-keto thioethers and arynes undergo efficient rearrangement allowing the facile and robust synthesis of functionalized enol ethers in high yields and excellent functional group compatibility. Preliminary mechanistic studies rule out the possibility of Pummerer-type rearrangement operating in this case.

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