(E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide

Base Information

• Chemical Name: (E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide
• CAS No.: 59675-63-7
• Molecular Formula: C₁₉H₁₆NOP
• Molecular Weight: 305.316
• Mol file: 59675-63-7.mol

Synonyms:(E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide

Chemical Property of (E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide

There total 6 articles about (E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-ethynylpyridine (1945-84-2) + Diphenylphosphine oxide (4559-70-0) → (E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide (59675-63-7)

Guidance literature:

With diphosphino-functionalized MCM-41-immobilized rhodium complex; In toluene; at 80 ℃; for 6h; stereoselective reaction; Inert atmosphere;

DOI:10.1007/s10562-012-0781-9

Reference yield: 75.0%

pyridine-2-carbaldehyde (1121-60-4) + diphenylphosphorylacetic acid (1831-63-6) → (E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide (59675-63-7) + [2-(pyridin-2-yl)vinyl]diphenylphosphine oxide (1429762-85-5)

Guidance literature:

With piperidine; acetic acid; In acetonitrile; at 80 ℃; for 12h; stereoselective reaction; Molecular sieve; Green chemistry;

DOI:10.1055/s-0040-1705993

Reference yield: 66.0%

Diphenylphosphine oxide (4559-70-0) + (E)-3-(2-pyridyl)acrylic acid (54495-51-1) → (E)-(2-(pyridin-2-yl)vinyl)diphenylphosphine oxide (59675-63-7)

Guidance literature:

With dipotassium hydrogenphosphate; tert-Butyl peroxybenzoate; potassium iodide; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1021/acs.joc.8b00187

upstream raw materials:

2-ethynylpyridine

Diphenylphosphine oxide

(E)-3-(2-pyridyl)acrylic acid

pyridine-2-carbaldehyde

Downstream raw materials:

(E)-diphenyl(2-(pyridin-2-yl)vinyl)phosphine sulfide

Refernces

• 1、 Liu, Lixin,Zhou, Dan,Dong, Jianyu,Zhou, Yongbo,Yin, Shuang-Feng,Han, Li-Biao. "Transition-metal-free C-P bond formation via decarboxylative phosphorylation of cinnamic acids with P(O)H compounds". . p. 4190 - 4196. Retrieved 2018/04/14.
• 2、 Yao, Fang,Peng, Jian,Hao, Wenyan,Cai, Mingzhong. "Diphosphino-functionalized MCM-41-immobilized rhodium complex: A highly efficient and recyclable catalyst for the hydrophosphinylation of terminal alkynes". experimental part. p. 803 - 808. Retrieved 2012/09/07.