3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane

Base Information

• Chemical Name: 3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane
• CAS No.: 321365-70-2
• Molecular Formula: C₂₂H₂₆F₂N₂O
• Molecular Weight: 372.458
• Mol file: 321365-70-2.mol

Synonyms:3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane

Chemical Property of 3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane

There total 1 articles about 3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[bis(4-fluorophenyl)methoxy]ethyl chloride (50366-31-9) + 8-methyl-3,8-diazabicyclo<3.2.1>octane hydrochloride (17783-50-5) → 3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane (321365-70-2)

Guidance literature:

With potassium carbonate; triethylamine; In toluene; for 48h; Heating;

DOI:10.1021/jm000300r

Reference yield:

3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane (321365-70-2) → 3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]octane (321365-72-4)

Guidance literature:

3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane; With potassium carbonate; 2,2,2-Trichloroethyl chloroformate; In toluene; Heating;

With acetic acid; zinc; at 20 ℃; Further stages.;

DOI:10.1021/jm000300r

Reference yield:

3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-methyl-3,8-diaza-bicyclo[3.2.1]octane (321365-70-2) → 3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-(3-phenyl-propyl)-3,8-diaza-bicyclo[3.2.1]octane

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2,2,2-trichloroethyl chloroformate; K₂CO₃ / toluene / Heating

1.2: Zn; AcOH / 20 °C

2.1: CH₂Cl₂ / 0.5 h / 20 °C

3.1: AlH₃ / tetrahydrofuran / 20 °C

With aluminium hydride; potassium carbonate; 2,2,2-Trichloroethyl chloroformate; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm000300r

upstream raw materials:

2-[bis(4-fluorophenyl)methoxy]ethyl chloride

8-methyl-3,8-diazabicyclo<3.2.1>octane hydrochloride

Downstream raw materials:

3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]octane

1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)(1H-indol-2-yl)methanone