(1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine

Base Information

Chemical Name:(1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine
CAS No.:112680-52-1
Molecular Formula:C₁₅H₂₉NO₃
Molecular Weight:271.4
Hs Code.:

Synonyms:(1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine

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Chemical Property of (1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine

Chemical Property:

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Technology Process of (1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine

There total 6 articles about (1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78756-21-5
(11aS)-6-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo<2.1-c><1,4>benzodiazepine-5,11-dione

: 112680-52-1
(1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 5 min, 2.) THF, -78 deg C, 5 min

2: 83 percent / t-BuOH, K / Birch reduction

3: H₂SO₄ / methanol / Heating

4: triethylamine

5: 1.) H₂SO₄, 2.) LiAlH₄ / 1.) MeOH, 100 deg C, 40 h, 2.) THF, RT, 24 h

6: 1.) Na, 2.) 2N NaOH / 1.) NH₃

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; sodium; triethylamine; tert-butyl alcohol; In methanol;
DOI:10.1021/jo00242a007

Reference yield:

: 112680-49-6
(5aS,6S,9aS,11aS)-perhydro-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione

: 112680-52-1
(1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄ / methanol / Heating

2: triethylamine

3: 1.) H₂SO₄, 2.) LiAlH₄ / 1.) MeOH, 100 deg C, 40 h, 2.) THF, RT, 24 h

4: 1.) Na, 2.) 2N NaOH / 1.) NH₃

With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; sodium; triethylamine; In methanol;
DOI:10.1021/jo00242a007

Reference yield:

: 112680-48-5
6-n-propyl-1,2,3,10,11,11a(S)-hexahydro-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione

: 112680-52-1
(1S,2S,3S)-2-(hydroxymethyl)-3-n-propyl-N-(benzyloxycarbonyl)cyclohexylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / t-BuOH, K / Birch reduction

2: H₂SO₄ / methanol / Heating

3: triethylamine

4: 1.) H₂SO₄, 2.) LiAlH₄ / 1.) MeOH, 100 deg C, 40 h, 2.) THF, RT, 24 h

5: 1.) Na, 2.) 2N NaOH / 1.) NH₃

With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; sodium; triethylamine; tert-butyl alcohol; In methanol;
DOI:10.1021/jo00242a007