2-Formyl-4-(tributylstannyl)thiazole

Base Information

• Chemical Name: 2-Formyl-4-(tributylstannyl)thiazole
• CAS No.: 231278-14-1
• Molecular Formula: C₁₆H₂₉NOSSn
• Molecular Weight: 402.188
• DSSTox Substance ID: DTXSID90586025
• Wikidata: Q82478054
• Mol file: 231278-14-1.mol

Synonyms:2-Formyl-4-(tributylstannyl)thiazole;231278-14-1;4-tributylstannyl-1,3-thiazole-2-carbaldehyde;4-(tributylstannyl)thiazole-2-carbaldehyde;4-(tributylstannyl)-1,3-thiazole-2-carbaldehyde;MFCD09025791;2-Thiazolecarboxaldehyde, 4-(tributylstannyl)-;C16H29NOSSn;SCHEMBL3318443;DTXSID90586025;SWNXZUKRZWHDGZ-UHFFFAOYSA-N;AKOS015837497;AT11398;SY318944;2-formyl-4-(tributylstannyl)thiazole, AldrichCPR;4-(Tributylstannyl)-1,3-thiazole-2-carboxaldehyde;J-509535

Chemical Property of 2-Formyl-4-(tributylstannyl)thiazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 11
• Exact Mass: 403.099188
• Heavy Atom Count: 20
• Complexity: 253

Purity/Quality:

97% ^*data from raw suppliers

2-Formyl-4-(tributylstannyl)thiazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC[Sn](CCCC)(CCCC)C1=CSC(=N1)C=O

Technology Process of 2-Formyl-4-(tributylstannyl)thiazole

There total 1 articles about 2-Formyl-4-(tributylstannyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-morpholinecarboxaldehyde (4394-85-8) + C15H28BrNSSn (1062589-73-4) → 4-(tributylstannanyl)-1,3-thiazole-2-carbaldehyde (231278-14-1)

Guidance literature:

C₁₅H₂₈BrNSSn; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -90 - -85 ℃; for 0.5h;

4-morpholinecarboxaldehyde; In tetrahydrofuran; pentane; at -90 - 0 ℃; for 0.666667h;

Reference yield: 45.0%

4-(tributylstannanyl)-1,3-thiazole-2-carbaldehyde (231278-14-1) + C15H9ClFIN2O (1062589-81-4) → C19H11ClFN3O2S (1062589-85-8)

Guidance literature:

PdCl₂(PPh₂(CH₂)4PPh₂); In 1,4-dioxane; at 120 ℃; for 18h; Heating / reflux;

Reference yield: 44.0%

4-(tributylstannanyl)-1,3-thiazole-2-carbaldehyde (231278-14-1) + (4-phenoxyphenyl)-(7-iodoquinolin-4-yl)amine → 4-(4-(4-phenoxyphenylamino)-quinolin-7-yl) thiazole-2-carbaldehyde

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; Inert atmosphere;

upstream raw materials:

4-morpholinecarboxaldehyde

C₁₅H₂₈BrNSSn

Downstream raw materials:

C₁₉H₁₁ClFN₃O₂S