(E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide

Base Information

Chemical Name:(E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide
CAS No.:1426943-21-6
Molecular Formula:C₃₃H₂₈N₂O₄
Molecular Weight:516.596
Hs Code.:

Synonyms:(E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide

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Chemical Property of (E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide

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Technology Process of (E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide

There total 12 articles about (E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1426943-06-7
2-(2-((2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)ethyl)isoindoline-1,3-dione

: 1426943-40-9
(E)-3-(4-bromo-3'-methyl[1,1'-biphenyl]-2-yl)acrylamide

: 1426943-21-6
(E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride; In 1,2-dimethoxyethane; at 80 ℃; for 15h; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201203005

Reference yield:

: 3891-07-4
N-(2-Hydroxyethyl)phthalimide

: 1426943-21-6
(E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 40 °C / Inert atmosphere; Schlenk technique

1.2: 1.5 h / 70 °C / Inert atmosphere; Schlenk technique

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Schlenk technique

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,2-dimethoxyethane / 15 h / 80 °C / Inert atmosphere; Schlenk technique

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; cesium fluoride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki Coupling;
DOI:10.1002/chem.201203005

Reference yield:

: 17933-03-8
m-tolylboronic acid

: 1426943-21-6
(E)-3-(2''-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-3-methyl[1,1':4',1'']terphenyl-2'-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogen bifluoride / methanol; water / 2 h / 20 °C

2: palladium diacetate / methanol / -78 - 9 °C / Inert atmosphere; Schlenk technique

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,2-dimethoxyethane / 15 h / 80 °C / Inert atmosphere; Schlenk technique

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium hydrogen bifluoride; palladium diacetate; cesium fluoride; In methanol; 1,2-dimethoxyethane; water; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1002/chem.201203005