N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

Base Information

Chemical Name:N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide
CAS No.:866553-65-3
Molecular Formula:C₂₄H₂₃F₃N₂O₃S
Molecular Weight:476.519
Hs Code.:

<i>N</i>-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

Synonyms:N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

Suppliers and Price of N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

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Technology Process of N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

There total 9 articles about N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 866553-59-5
3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionic acid

: 622-33-3
N-benzyloxyamine

: 866553-65-3
N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

Guidance literature:: With bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; for 2h;
DOI:10.1016/j.tetlet.2005.07.078

Reference yield:

: 866553-53-9
3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionic acid ethyl ester

: 866553-65-3
N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / KOH / H₂O; methanol / 80 °C

2: 76 percent / PyBrOP / CH₂Cl₂ / 2 h

With potassium hydroxide; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2005.07.078

Reference yield:

: 866553-45-9
2-benzyloxycarbonylamino-3,3,3-trifluoro-2-(4-phenoxy-phenylsulfanylmethyl)-propionic acid ethyl ester

: 866553-65-3
N-benzyloxy-3,3,3-trifluoro-2-methylamino-2-(4-phenoxy-phenylsulfanylmethyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / NaH / 2 h / 0 - 20 °C

2: 97 percent / HBr / acetic acid / 2 h / 20 °C

3: 77 percent / KOH / H₂O; methanol / 80 °C

4: 76 percent / PyBrOP / CH₂Cl₂ / 2 h

With potassium hydroxide; hydrogen bromide; sodium hydride; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane; water; acetic acid;
DOI:10.1016/j.tetlet.2005.07.078