2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

Base Information

Chemical Name:2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide
CAS No.:566920-43-2
Molecular Formula:C₂₈H₃₄FNO₅
Molecular Weight:483.58
Hs Code.:

Synonyms:2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

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Chemical Property of 2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

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Technology Process of 2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

There total 7 articles about 2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 934391-82-9
4-(5-fluoro-2-methoxy-phenyl)-4-methyl-2-oxo-pentanoic acid (1-oxo-1,3-dihydro-isobenzofuran-5-yl)-amide

: 35166-78-0
cyclohexylmethyl magnesium bromide

: 566920-43-2
2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

Guidance literature:: at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2005.07.025

Reference yield:

: 217196-31-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid

: 566920-43-2
2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-acetamide / 0 °C

2: N,N-dimethyl-acetamide / 0 - 20 °C

3: 60 percent / 0 - 20 °C

With thionyl chloride; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2005.07.025

Reference yield:

: 566920-34-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid ethyl ester

: 566920-43-2
2-cyclohexylmethyl-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / aq. KOH / ethanol / Heating

2: thionyl chloride / N,N-dimethyl-acetamide / 0 °C

3: N,N-dimethyl-acetamide / 0 - 20 °C

4: 60 percent / 0 - 20 °C

With potassium hydroxide; thionyl chloride; In ethanol; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2005.07.025