3-chloro-1-(4-fluorophenyl)propyl butyrate

Base Information

• Chemical Name: 3-chloro-1-(4-fluorophenyl)propyl butyrate
• CAS No.: 1345507-81-4
• Molecular Formula: C₁₃H₁₆ClFO₂
• Molecular Weight: 258.72
• Mol file: 1345507-81-4.mol

Synonyms:3-chloro-1-(4-fluorophenyl)propyl butyrate

Chemical Property of 3-chloro-1-(4-fluorophenyl)propyl butyrate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-chloro-1-(4-fluorophenyl)propyl butyrate

There total 2 articles about 3-chloro-1-(4-fluorophenyl)propyl butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

vinyl n-butyrate (123-20-6,24991-31-9) + 3-chloro-1-(4-fluorophenyl)propan-1-ol (31736-75-1) → 3-chloro-1-(4-fluorophenyl)propyl butyrate (1345507-81-4)

Guidance literature:

With lipase A from candida antarctica; In hexane; at 20 ℃; for 24h; Enzymatic reaction;

DOI:10.1055/s-0030-1260149

Reference yield:

3-chloro-4'-fluoropropiophenone (347-93-3) → 3-chloro-1-(4-fluorophenyl)propyl butyrate (1345507-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / -20 - -15 °C

2: lipase A from candida antarctica / hexane / 24 h / 20 °C / Enzymatic reaction

With sodium tetrahydroborate; lipase A from candida antarctica; In ethanol; hexane;

DOI:10.1055/s-0030-1260149

upstream raw materials:

vinyl n-butyrate

3-chloro-1-(4-fluorophenyl)propan-1-ol

3-chloro-4'-fluoropropiophenone

Refernces