31736-75-1

Basic information

• Product Name: 3-chloro-1-(4-fluorophenyl)propan-1-ol
• Synonyms: 3-chloro-1-(4-fluorophenyl)propan-1-ol
• CAS NO: 31736-75-1
• Molecular Formula: C₉H₁₀ClFO
• Molecular Weight: 188.6265032
• Mol File: 31736-75-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-chloro-1-(4-fluorophenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(4-fluorophenyl)propan-1-ol(31736-75-1)
• EPA Substance Registry System: 3-chloro-1-(4-fluorophenyl)propan-1-ol(31736-75-1)

Safety Data

• Hazardous Substances Data: 31736-75-1(Hazardous Substances Data)

Upstream product

• 347-93-3 3-chloro-4'-fluoropropiophenone 
• 462-06-6 fluorobenzene 

Downstream Products

• 639467-53-1 1-(3-chloro-1-(4-fluorophenyl)propoxy)-4-nitrobenzene 
• 52867-93-3 1-(1-bromo-3-chloropropyl)-4-fluorobenzene 
• 31736-68-2 2-(4'-fluorophenyl)oxetane 
• 1352742-02-9 (R)-3-chloro-1-(4-fluorophenyl)propyl acetate 
• 200004-39-3 (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol 
• 1345507-84-7 (R)-3-chloro-1-(4-fluorophenyl)propyl butyrate 
• 200004-40-6 (S)-3-chloro-1-(4-fluorophenyl)propan-1-ol 
• 1345507-81-4 3-chloro-1-(4-fluorophenyl)propyl butyrate 

Relevant articles and documents

ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1)

The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter

Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and selective NET ligand 1-(3-(methylamino)-1-phenylpropyl)-3-phenyl-1,3-dihydro-2H-benzimidaz- ol-2-one (Me@APPI), this paper aims at the development of several fluorinated methylaminebased analogs of this compound. The newly synthesized compounds were computationally evaluated for their interactions with the monoamine transporters and represent reference compounds for PET-based investigation of the NET.

1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies

New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 μg/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC ≤ 5 μg/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.