(E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid

Base Information

Chemical Name:(E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid
CAS No.:1574636-24-0
Molecular Formula:C₂₀H₂₄N₂O₈S
Molecular Weight:452.485
Hs Code.:

Synonyms:(E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid

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Chemical Property of (E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid

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Technology Process of (E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid

There total 9 articles about (E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1574636-22-8
(E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

: 1574636-24-0
(E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid

Guidance literature:: (E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate; With sodium carbonate; In methanol; water; at 20 ℃; for 18h;

With hydrogenchloride; In water; pH=2;
DOI:10.1021/jm4019614

Reference yield:

: 1353547-96-2
methyl 2-(((5-methoxy-6-nitropyridin-2-yl)methyl)thio)acetate

: 1574636-24-0
(E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: dihydrogen peroxide; acetic acid / water / 12 h / 50 °C

2.1: potassium carbonate / water; methanol / 12 h / 20 °C

3.1: piperidine; benzoic acid / toluene / 4 h / Reflux; Dean-Stark

4.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h

5.2: 18 h / 20 °C

6.1: sodium carbonate / water; methanol / 18 h / 20 °C

6.2: pH 2

With piperidine; dihydrogen peroxide; iron; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; benzoic acid; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm4019614

Reference yield:

: 24015-98-3
3-methoxy-6-methyl-2-nitro-pyridine

: 1574636-24-0
(E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 0.75 h / 120 °C / Microwave irradiation

2.1: potassium carbonate / methanol / 12 h / 0 - 20 °C

3.1: dihydrogen peroxide; acetic acid / water / 12 h / 50 °C

4.1: potassium carbonate / water; methanol / 12 h / 20 °C

5.1: piperidine; benzoic acid / toluene / 4 h / Reflux; Dean-Stark

6.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h

7.2: 18 h / 20 °C

8.1: sodium carbonate / water; methanol / 18 h / 20 °C

8.2: pH 2

With piperidine; N-Bromosuccinimide; dihydrogen peroxide; iron; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; benzoic acid; dibenzoyl peroxide; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm4019614