(E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

Base Information

Chemical Name:(E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate
CAS No.:1574636-22-8
Molecular Formula:C₂₂H₂₈N₂O₈S
Molecular Weight:480.539
Hs Code.:

Synonyms:(E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

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Chemical Property of (E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

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Technology Process of (E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

There total 8 articles about (E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1353547-84-8
(E)-3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-amine

: 105-36-2
ethyl bromoacetate

: 1574636-22-8
(E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

Guidance literature:: (E)-3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; for 1h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm4019614

Reference yield:

: 24015-98-3
3-methoxy-6-methyl-2-nitro-pyridine

: 1574636-22-8
(E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 0.75 h / 120 °C / Microwave irradiation

2.1: potassium carbonate / methanol / 12 h / 0 - 20 °C

3.1: dihydrogen peroxide; acetic acid / water / 12 h / 50 °C

4.1: potassium carbonate / water; methanol / 12 h / 20 °C

5.1: piperidine; benzoic acid / toluene / 4 h / Reflux; Dean-Stark

6.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h

7.2: 18 h / 20 °C

With piperidine; N-Bromosuccinimide; dihydrogen peroxide; iron; sodium hydride; potassium carbonate; acetic acid; benzoic acid; dibenzoyl peroxide; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm4019614

Reference yield:

: 1353548-00-1
methyl 2-(((5-methoxy-6-nitropyridin-2-yl)methyl)sulfonyl)acetate

: 1574636-22-8
(E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / water; methanol / 12 h / 20 °C

2.1: piperidine; benzoic acid / toluene / 4 h / Reflux; Dean-Stark

3.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h

4.2: 18 h / 20 °C

With piperidine; iron; sodium hydride; potassium carbonate; acetic acid; benzoic acid; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm4019614