N₃-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide

Base Information

• Chemical Name: N₃-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide
• CAS No.: 1256650-55-1
• Molecular Formula: C₁₈H₂₈N₂O₂
• Molecular Weight: 304.433
• Mol file: 1256650-55-1.mol

Synonyms:N₃-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide

Chemical Property of N₃-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₃-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide

There total 4 articles about N₃-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxylic acid (1256382-85-0) + cyclohexylamine (108-91-8,157973-60-9) → N3-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide (1256650-55-1)

Guidance literature:

6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

cyclohexylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm3008568

Reference yield: 27.0%

→ N3-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide (1256650-55-1)

Guidance literature:

Reference yield:

(E/Z)-3-((dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione (33821-61-3) → N3-(cyclohexyl)-6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxamide (1256650-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / ethanol / 12 h / Reflux

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2.2: 16 h / 20 °C

With potassium tert-butylate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1021/jm3008568

upstream raw materials:

(E/Z)-3-((dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione

6-methyl-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxylic acid

cyclohexylamine

n-Pentylamine