[(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

Base Information

Chemical Name:[(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid
CAS No.:857040-91-6
Molecular Formula:C₂₂H₂₅N₃O₆
Molecular Weight:427.457
Hs Code.:

Synonyms:[(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

Suppliers and Price of [(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

There total 10 articles about [(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 857041-20-4
[2-(4-tert-butoxy-benzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-acetaldehyde

: 857040-91-6
[(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In tert-butyl alcohol; at 0 ℃; for 2h;
DOI:10.1021/jm0491492

Reference yield:

: 857040-81-4
2-(2-chloro-3-nitro-benzylamino)ethanol

: 857040-91-6
[(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 2.46 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 5 h / 20 °C

2: 95 percent / HATU; diisopropylethylamine / CH₂Cl₂ / 20 °C

3: 95 percent / DBU / tetrahydrofuran / 2 h / 20 °C

4: 82 percent / triethylamine / dimethylsulfoxide / 24 h / 100 °C

5: 89 percent / TBAF / tetrahydrofuran / 1.5 h

6: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - -30 °C

7: aq. sodium chlorite; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 2 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol; 6: Swern oxidation;
DOI:10.1021/jm0491492

Reference yield:

: 857040-83-6
[2-(tert-butyldiphenylsilanyloxy)ethyl]-(2-chloro-3-nitrobenzyl)amine

: 857040-91-6
[(2S)-2-(tert-butoxybenzyl)-9-nitro-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / HATU; diisopropylethylamine / CH₂Cl₂ / 20 °C

2: 95 percent / DBU / tetrahydrofuran / 2 h / 20 °C

3: 82 percent / triethylamine / dimethylsulfoxide / 24 h / 100 °C

4: 89 percent / TBAF / tetrahydrofuran / 1.5 h

5: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - -30 °C

6: aq. sodium chlorite; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 2 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol; 5: Swern oxidation;
DOI:10.1021/jm0491492