2-(2-Methoxynaphthalen-1-yl)ethanamine

Base Information

• Chemical Name: 2-(2-Methoxynaphthalen-1-yl)ethanamine
• CAS No.: 156482-75-6
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.268
• European Community (EC) Number: 837-936-1
• Mol file: 156482-75-6.mol

Synonyms:156482-75-6;2-(2-methoxynaphthalen-1-yl)ethanamine;2-(2-methoxy-1-naphthyl)ethanamine;2-(2-methoxy-1-naphthyl)ethanamine(SALTDATA: HCl);2-(2-methoxynaphthyl)ethylamine;SCHEMBL1254856;IBGVDLDIASPYHY-UHFFFAOYSA-N;2-(2-methoxy-1-naphthyl)ethylamine;MFCD08448793;AKOS005292484;2-(2-methoxynaphthalen-1-yl)ethan-1-amine;EN300-657127

Chemical Property of 2-(2-Methoxynaphthalen-1-yl)ethanamine

Chemical Property:

• Boiling Point: 343.5±17.0 °C(Predicted)
• PKA: 9.45±0.10(Predicted)
• Density: 1.093±0.06 g/cm3(Predicted)
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 201.115364102
• Heavy Atom Count: 15
• Complexity: 195

Purity/Quality:

2-(2-methoxynaphthalen-1-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C2=CC=CC=C2C=C1)CCN

Technology Process of 2-(2-Methoxynaphthalen-1-yl)ethanamine

There total 8 articles about 2-(2-Methoxynaphthalen-1-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-NITRO-2-(2-METHOXY-1-NAPHTHYL)ETHYLENE (116272-79-8) → 2-(2-methoxynaphthalen-1-yl)ethan-1-amine (156482-75-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 40 ℃; for 24h;

DOI:10.1021/jm00012a004

Reference yield:

2-methoxy-1-naphthaldehyde (5392-12-1) → 2-(2-methoxynaphthalen-1-yl)ethan-1-amine (156482-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / ammonium acetate / 2 h / Heating

2: 79 percent / LiAlH₄ / tetrahydrofuran / 24 h / 40 °C

With ammonium acetate; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm00012a004

Reference yield:

3-(2-methoxy-[1]naphthyl)-propionic acid hydrazide → 2-(2-methoxynaphthalen-1-yl)ethan-1-amine (156482-75-6)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; Erwaermen des Azids mit wss.HCl auf 60-65grad;

DOI:10.1021/jo01126a017

upstream raw materials:

[2-(2-methoxy-[1]naphthyl)-ethyl]-carbamic acid ethyl ester

1-NITRO-2-(2-METHOXY-1-NAPHTHYL)ETHYLENE

2-methoxy-1-naphthaldehyde

splitomicin

Downstream raw materials:

N-<2-(2-methoxynaphthyl)ethyl>-n-valeramide

N-<2-(2-methoxynaphthyl)ethyl>cyclopropylformamide

Refernces

• 1、 Langlois, Michel,Bremont, Beatrice,Shen, Shuren,Poncet, Annie,Andrieux, Jean,et al.. "Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-Iodomelatonin Binding Sites". . p. 2050 - 2060. Retrieved 2007/10/02.