(4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid

Base Information

• Chemical Name: (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid
• CAS No.: 958457-42-6
• Molecular Formula: C₁₃H₁₀BF₃O₃
• Molecular Weight: 282.027
• Mol file: 958457-42-6.mol

Synonyms:(4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid

Chemical Property of (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid

There total 4 articles about (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-(4-bromophenoxy)-benzotrifluoride (109272-29-9) → (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid (958457-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: hydrogenchloride / water / 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

C19H22BF3O3 → (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid (958457-42-6)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

4-bromo-phenol (106-41-2) → (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid (958457-42-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetramethyl-heptanedione; caesium carbonate; copper(l) chloride / 1-methyl-pyrrolidin-2-one / 100 °C

2: n-butyllithium / tetrahydrofuran / -78 °C

3: hydrogenchloride / water / 20 °C

With hydrogenchloride; n-butyllithium; tetramethyl-heptanedione; caesium carbonate; copper(l) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water;

DOI:10.1016/j.bmcl.2011.07.044

upstream raw materials:

meta-(4-bromophenoxy)-benzotrifluoride

4-bromo-phenol

m-trifluoromethylphenyl iodide

Downstream raw materials:

6-methyl-2-(O-tert-butyldimethylsilyl)hydroxymethyl-3-(4-[3-(trifluoromethyl)phenyl]oxy)-pyran-4(1H)-one

6-(hydroxymethyl)-2-methyl-3-(4-{[3(trifluoromethy)phenyl]oxy}phenyl)-4H-pyran-4-one

6-(hydroxymethyl)-2-methyl-3-(4-{[3(trifluoromethy)phenyl]oxy}phenyl)-pyridin-4(1H)-one

Refernces

• 1、 -. "Novel heterocyclic compounds". Page/Page column 28. . Retrieved 2008/06/13.