109272-29-9

Upstream product

• 106-41-2 4-bromo-phenol 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 3586-15-0 3-phenoxy-benzoyl chloride 
• 106-37-6 1.4-dibromobenzene 
• 98-17-9 3-Trifluoromethylphenol 
• 109272-26-6 1-Phenoxy-3-(tris-ethylsulfanyl-methyl)-benzene 

Downstream Products

• 330-58-5 phenyl m-α,α,α-trifluorotolyl ether 
• 958457-42-6 (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid 
• 958457-37-9 6-(hydroxymethyl)-2-methyl-3-(4-{[3(trifluoromethy)phenyl]oxy}phenyl)-pyridin-4(1H)-one 
• 958457-35-7 6-(hydroxymethyl)-2-methyl-3-(4-{[3(trifluoromethy)phenyl]oxy}phenyl)-4H-pyran-4-one 
• 958457-29-9 6-methyl-2-(O-tert-butyldimethylsilyl)hydroxymethyl-3-(4-[3-(trifluoromethyl)phenyl]oxy)-pyran-4(1H)-one 

Relevant academic research and scientific papers

Potent antimalarial 4-pyridones with improved physico-chemical properties

Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous medi

Novel heterocyclic compounds

4-pyridone derivatives of Formula I and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulations thereof and their use in chemotherapy of certain parasitic infections such as malaria, are provided.

Novel aryl ether sulfones

Disclosed is an aryl ether sulfone of the following formula: STR1 wherein R1 is independently in each occurrence hydrogen, alkyl, alkoxy, aryl, aryloxy, polyhaloaryl, polyhaloaryloxy, polyhaloalkylaryl, or polyhaloalkylaryloxy, R2 is

A FACILE SYNTHESIS OF AROMATIC TRIFLUOROMETHYL COMPOUNDS VIA ORTHOTHIO ESTERS

Aromatic trifluoromethyl compounds (2) are prepared by treatment of aromatic orthothio esters (1) with 1,3-dibromo-5,5-dimethylhydantoin (DBH) or N-bromosuccinimide (NBS) followed by HF/pyridine complex.The starting materials (1) were readily obtained by literature methodology.