Technology Process of carbonic acid 5-[2-(tert-butyl-dimethyl-silanyloxy)-5-fluoro-phenyl]-pent-2-enyl ester methyl ester
There total 11 articles about carbonic acid 5-[2-(tert-butyl-dimethyl-silanyloxy)-5-fluoro-phenyl]-pent-2-enyl ester methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: K2CO3 / acetone
2.1: 240 °C
3.1: imidazole / CH2Cl2
4.1: BH3 / tetrahydrofuran
4.2: NaOH; H2O2
5.1: PCC; molecular sieves 4A / CH2Cl2
6.1: 85 percent / potassium carbonate / methanol / 20 °C
7.1: 83 percent / imidazole / CH2Cl2 / 20 °C
8.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
8.2: 84 percent / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
9.1: 81 percent / Lindlar's catalyst; H2 / methanol / 18 h / 20 °C / 760 Torr
10.1: pyridine / CH2Cl2
With
pyridine; 1H-imidazole; Lindlar's catalyst; n-butyllithium; 4 A molecular sieve; borane; hydrogen; potassium carbonate; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; acetone;
DOI:10.1021/ja048078t
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 240 °C
2.1: imidazole / CH2Cl2
3.1: BH3 / tetrahydrofuran
3.2: NaOH; H2O2
4.1: PCC; molecular sieves 4A / CH2Cl2
5.1: 85 percent / potassium carbonate / methanol / 20 °C
6.1: 83 percent / imidazole / CH2Cl2 / 20 °C
7.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
7.2: 84 percent / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
8.1: 81 percent / Lindlar's catalyst; H2 / methanol / 18 h / 20 °C / 760 Torr
9.1: pyridine / CH2Cl2
With
pyridine; 1H-imidazole; Lindlar's catalyst; n-butyllithium; 4 A molecular sieve; borane; hydrogen; potassium carbonate; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ja048078t
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: imidazole / CH2Cl2
2.1: BH3 / tetrahydrofuran
2.2: NaOH; H2O2
3.1: PCC; molecular sieves 4A / CH2Cl2
4.1: 85 percent / potassium carbonate / methanol / 20 °C
5.1: 83 percent / imidazole / CH2Cl2 / 20 °C
6.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
6.2: 84 percent / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
7.1: 81 percent / Lindlar's catalyst; H2 / methanol / 18 h / 20 °C / 760 Torr
8.1: pyridine / CH2Cl2
With
pyridine; 1H-imidazole; Lindlar's catalyst; n-butyllithium; 4 A molecular sieve; borane; hydrogen; potassium carbonate; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ja048078t
