2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile

Base Information

• Chemical Name: 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile
• CAS No.: 1229027-91-1
• Molecular Formula: C₂₃H₂₁N₇S
• Molecular Weight: 427.533

Synonyms:2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile

Chemical Property of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile

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Technology Process of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile

There total 1 articles about 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

piperazine (110-85-0) + 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-chloro-6-phenylpyrimidine-5-carbonitrile (1229027-80-8) → 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile (1229027-91-1)

Guidance literature:

With potassium carbonate; In ethanol; at 20 ℃; Reflux;

DOI:10.1016/j.ejmech.2010.02.011

Reference yield: 88.0%

2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile (1229027-91-1) + p-toluenesulfonyl chloride (98-59-9) → 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(4-tosylpiperazin-1-yl)pyrimidine-5-carbonitrile (1229027-98-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1016/j.ejmech.2010.02.011

Reference yield: 86.0%

2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(piperazin-1-yl)pyrimidine-5-carbonitrile (1229027-91-1) + phenylacetyl chloride (103-80-0) → 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(4-(2-phenylacetyl)piperazin-1-yl)pyrimidine-5-carbonitrile (1229027-96-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1016/j.ejmech.2010.02.011

upstream raw materials:

piperazine

2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-chloro-6-phenylpyrimidine-5-carbonitrile

Downstream raw materials:

2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(4-tosylpiperazin-1-yl)pyrimidine-5-carbonitrile

2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-6-(4-(2-phenylacetyl)piperazin-1-yl)pyrimidine-5-carbonitrile

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