3'-(4-Fluorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione

Base Information

Chemical Name:3'-(4-Fluorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione
CAS No.:79962-58-6
Molecular Formula:C₁₆H₁₁FN₂O₂S
Molecular Weight:314.34
Hs Code.:
DSSTox Substance ID:DTXSID201160241
Nikkaji Number:J529.820B
Mol file:79962-58-6.mol

Synonyms:79962-58-6;3'-(4-fluorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione;3-(4-fluorophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione;3'-(4-fluorophenyl)-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione;ChemDiv1_012787;Oprea1_831030;HMS623F05;YDCAABKMMODBCJ-UHFFFAOYSA-N;DTXSID201160241;CCG-49058;MFCD01423226;STK824458;AKOS000644000;spiro 2',2'-[N-(4'-fluorophenyl)-thiazolidin-4'-one]-3,3-[oxindole];3-(4-fluorophenyl)-1',3'-dihydrospiro[1,3-thiazolidine-2,3'-(2'H)-indole]-2',4-dione;NCGC00318058-01;12E-358S;EU-0060420;AB01312274-01;AO-476/40166263;SR-01000638542-1;3'-(4-Fluorophenyl)spiro[3H-indole-3,2'-thiazolidine]-2(1H),4'-dione;3'-(4-Fluorophenyl)spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione

Suppliers and Price of 3'-(4-Fluorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3'-(4-Fluorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione

Chemical Property:

Melting Point:245 °C
Boiling Point:670.7±55.0 °C(Predicted)
PKA:12.85±0.20(Predicted)
Density:1.53±0.1 g/cm3(Predicted)
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:314.05252693
Heavy Atom Count:22
Complexity:495

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(=O)N(C2(S1)C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)F

Technology Process of 3'-(4-Fluorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione

There total 7 articles about 3'-(4-Fluorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 68-11-1
mercaptoacetic acid

: 371-40-4
4-fluoroaniline

: 79962-58-6
3'-(4-fluorophenyl)spiro<3H-indole-3,2'-thiazolidine>-2,4'(1H)-dione

Guidance literature:: With hypercrosslinked 1-aminopropyl-3-vinylimidazolium bromide based poly ionic liquid immobilized on vinyl functionalized Co₃O₄ nanoparticles; In water; at 25 ℃; for 0.266667h; Sonication;
DOI:10.1039/d0ra08647a

Reference yield: 82.0%

: 21231-47-0
3-((4-fluorophenyl)imino)indolin-2-one

: 68-11-1
mercaptoacetic acid

: 79962-58-6
3'-(4-fluorophenyl)spiro<3H-indole-3,2'-thiazolidine>-2,4'(1H)-dione

Guidance literature:: In water; for 4.5h; Reflux;
DOI:10.1007/s00706-011-0697-x

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 79962-58-6
3'-(4-fluorophenyl)spiro<3H-indole-3,2'-thiazolidine>-2,4'(1H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: glacial CH₃COOH / ethanol / 2 h / Heating

2: benzene / Heating

With acetic acid; In ethanol; benzene;