(E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

Base Information

Chemical Name:(E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine
CAS No.:1384097-63-5
Molecular Formula:C₂₅H₂₃ClN₄O₃S
Molecular Weight:495.002
Hs Code.:

Synonyms:(E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

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Chemical Property of (E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

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Technology Process of (E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

There total 5 articles about (E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1384097-59-9
(E)-4-(benzylideneamino)-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione

: 611-17-6
1-bromomethyl-2-chlorobenzene

: 1384097-63-5
(E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

Guidance literature:: (E)-4-(benzylideneamino)-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione; With potassium carbonate; In acetone; for 0.5h; Reflux;

1-bromomethyl-2-chlorobenzene; In acetone; Reflux;
DOI:10.1016/j.bmcl.2012.03.023

Reference yield:

: 118-41-2
Eudesmic acid

: 1384097-63-5
(E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 12 h / Reflux

2.1: hydrazine hydrate / ethanol / 6 h / Reflux

3.1: potassium hydroxide / ethanol / 16 h / 20 °C

3.2: 3 h / Reflux

4.1: acetic acid / 2 h / Reflux

5.1: potassium carbonate / acetone / 0.5 h / Reflux

5.2: Reflux

With sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; acetone;
DOI:10.1016/j.bmcl.2012.03.023

Reference yield:

: 31821-78-0
4-amino-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione

: 1384097-63-5
(E)-N-benzylidene-3-(2-chlorobenzylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 2 h / Reflux

2.1: potassium carbonate / acetone / 0.5 h / Reflux

2.2: Reflux

With potassium carbonate; acetic acid; In acetone;
DOI:10.1016/j.bmcl.2012.03.023