(2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate

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Chemical Name:(2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate
CAS No.:1450837-84-9
Molecular Formula:C₂₁H₃₁N₃O₄S
Molecular Weight:421.561
Hs Code.:

Synonyms:(2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate

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Chemical Property of (2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate

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Technology Process of (2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate

There total 2 articles about (2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1125843-10-8
N²-(tert-butoxycarbonyl)-N⁶-ethanethioyl-L-lysine

: 5468-37-1
2-aminoacetophenone hydrochloride

: 1450837-84-9
(2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate

Guidance literature:: N²-(tert-butoxycarbonyl)-N⁶-ethanethioyl-L-lysine; With pyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

2-aminoacetophenone hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jm400438k

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 1450837-84-9
(2S)-2-tert-butyl 6-ethanethioamido-1-oxo-1-(2-oxo-2-phenylethylamino)hexan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / water; ethanol / 12 h / 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; pyridine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 2.5 h / 20 °C / Inert atmosphere

With pyridine; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400438k